Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for t...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/7150386 |
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| author | Jingzhu Lv Tao Xu Zhongqing Qian Hongtao Wang |
| author_facet | Jingzhu Lv Tao Xu Zhongqing Qian Hongtao Wang |
| author_sort | Jingzhu Lv |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC. However, the results are controversial or inconclusive. Hence, we conducted a meta-analysis to derive a more precise estimation of the associations. A total of 6 articles were used to evaluate the effect of the two polymorphisms on the risk of HBV-related HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian. Further validation of our results in larger populations and different ethnicities are required. |
| format | Article |
| id | doaj-art-4178dddf30b7404ea8515b6b4d46a598 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-4178dddf30b7404ea8515b6b4d46a5982025-08-20T02:08:25ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/71503867150386Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular CarcinomaJingzhu Lv0Tao Xu1Zhongqing Qian2Hongtao Wang3Department of Biochemistry and Molecular Biology, Bengbu Medical College, Bengbu 233003, ChinaDepartment of Clinical Laboratory, Bengbu Medical College, Bengbu, Anhui 233030, ChinaDepartment of Immunology, Bengbu Medical College, Bengbu Anhui 233030, ChinaDepartment of Immunology, Bengbu Medical College, Bengbu Anhui 233030, ChinaHepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC. However, the results are controversial or inconclusive. Hence, we conducted a meta-analysis to derive a more precise estimation of the associations. A total of 6 articles were used to evaluate the effect of the two polymorphisms on the risk of HBV-related HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian. Further validation of our results in larger populations and different ethnicities are required.http://dx.doi.org/10.1155/2017/7150386 |
| spellingShingle | Jingzhu Lv Tao Xu Zhongqing Qian Hongtao Wang Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma Gastroenterology Research and Practice |
| title | Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma |
| title_full | Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma |
| title_fullStr | Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma |
| title_full_unstemmed | Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma |
| title_short | Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma |
| title_sort | association between hla dq gene polymorphisms and hbv related hepatocellular carcinoma |
| url | http://dx.doi.org/10.1155/2017/7150386 |
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