Relationship between platelet distribution width and non-dipping pattern in children with essential hypertension
Abstract Background Hypertension has shown a trend of prevalence at younger ages, and the non-dipping pattern is associated with target organ damage in hypertension. However, few studies have yet investigated the clinical characteristics and risk factors of non-dipper status in essential hypertensio...
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BMC
2025-01-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-025-05420-2 |
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| author | Ling Sun Bo Wang Daoping Yang Wanping Zhou Yunjia Tang Xuan Li Haitao Lv Miao Hou |
| author_facet | Ling Sun Bo Wang Daoping Yang Wanping Zhou Yunjia Tang Xuan Li Haitao Lv Miao Hou |
| author_sort | Ling Sun |
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| description | Abstract Background Hypertension has shown a trend of prevalence at younger ages, and the non-dipping pattern is associated with target organ damage in hypertension. However, few studies have yet investigated the clinical characteristics and risk factors of non-dipper status in essential hypertension children. This study aimed to explore the clinical characteristics and possible indicators associated with non-dipper status in children with essential hypertension. Methods A total of 125 children (99 boys, 26 girls) with untreated essential hypertension were retrospectively included in this study. Non-dipping was defined as a nocturnal drop in systolic or diastolic BP (SBP, DBP) < 10%. Clinical data, ambulatory blood pressure monitoring (ABPM), laboratory and echocardiography parameters were recorded from the hospital database. Results Non-dipping pattern was found in 74 (59.2%) children and the dipping pattern in 51(40.8%) children, and the nocturnal SBP drop was 8.43 ± 0.71 (%), and the DBP drop was 14.44 ± 0.86 (%). The proportion of children with left ventricular hypertrophy was higher in the non-dipping group than in the dipping group. The platelet distribution width, high-sensitivity C-reactive protein (hs-CRP) and triglycerides (TG) levels were higher in the non-dipping group compared with the dipping group. In multivariate logistic regression analysis, PDW, TG and hs-CRP were found to be associated with the non-dipping pattern. Conclusion Non-dipping pattern in children hypertension is common, and the proportion of left ventricular hypertrophy is higher in non-dipping hypertension children. Moreover, higher PDW, hs-CRP and TG levels are the risk factors for non-dipping status in essential hypertension children. |
| format | Article |
| id | doaj-art-41744e5e584c4b05aeaee50668aa7abc |
| institution | Kabale University |
| issn | 1471-2431 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Pediatrics |
| spelling | doaj-art-41744e5e584c4b05aeaee50668aa7abc2025-01-26T12:52:49ZengBMCBMC Pediatrics1471-24312025-01-012511710.1186/s12887-025-05420-2Relationship between platelet distribution width and non-dipping pattern in children with essential hypertensionLing Sun0Bo Wang1Daoping Yang2Wanping Zhou3Yunjia Tang4Xuan Li5Haitao Lv6Miao Hou7Department of Cardiology, Children’s Hospital of Soochow UniversityDepartment of Cardiology, Children’s Hospital of Soochow UniversityDepartment of Cardiology, Children’s Hospital of Soochow UniversityDepartment of Cardiology, Children’s Hospital of Soochow UniversityDepartment of Cardiology, Children’s Hospital of Soochow UniversityDepartment of Cardiology, Children’s Hospital of Soochow UniversityDepartment of Cardiology, Children’s Hospital of Soochow UniversityDepartment of Cardiology, Children’s Hospital of Soochow UniversityAbstract Background Hypertension has shown a trend of prevalence at younger ages, and the non-dipping pattern is associated with target organ damage in hypertension. However, few studies have yet investigated the clinical characteristics and risk factors of non-dipper status in essential hypertension children. This study aimed to explore the clinical characteristics and possible indicators associated with non-dipper status in children with essential hypertension. Methods A total of 125 children (99 boys, 26 girls) with untreated essential hypertension were retrospectively included in this study. Non-dipping was defined as a nocturnal drop in systolic or diastolic BP (SBP, DBP) < 10%. Clinical data, ambulatory blood pressure monitoring (ABPM), laboratory and echocardiography parameters were recorded from the hospital database. Results Non-dipping pattern was found in 74 (59.2%) children and the dipping pattern in 51(40.8%) children, and the nocturnal SBP drop was 8.43 ± 0.71 (%), and the DBP drop was 14.44 ± 0.86 (%). The proportion of children with left ventricular hypertrophy was higher in the non-dipping group than in the dipping group. The platelet distribution width, high-sensitivity C-reactive protein (hs-CRP) and triglycerides (TG) levels were higher in the non-dipping group compared with the dipping group. In multivariate logistic regression analysis, PDW, TG and hs-CRP were found to be associated with the non-dipping pattern. Conclusion Non-dipping pattern in children hypertension is common, and the proportion of left ventricular hypertrophy is higher in non-dipping hypertension children. Moreover, higher PDW, hs-CRP and TG levels are the risk factors for non-dipping status in essential hypertension children.https://doi.org/10.1186/s12887-025-05420-2HypertensionChildrenNon-dipping patternPlatelet distribution widthLeft ventricular hypertrophy |
| spellingShingle | Ling Sun Bo Wang Daoping Yang Wanping Zhou Yunjia Tang Xuan Li Haitao Lv Miao Hou Relationship between platelet distribution width and non-dipping pattern in children with essential hypertension BMC Pediatrics Hypertension Children Non-dipping pattern Platelet distribution width Left ventricular hypertrophy |
| title | Relationship between platelet distribution width and non-dipping pattern in children with essential hypertension |
| title_full | Relationship between platelet distribution width and non-dipping pattern in children with essential hypertension |
| title_fullStr | Relationship between platelet distribution width and non-dipping pattern in children with essential hypertension |
| title_full_unstemmed | Relationship between platelet distribution width and non-dipping pattern in children with essential hypertension |
| title_short | Relationship between platelet distribution width and non-dipping pattern in children with essential hypertension |
| title_sort | relationship between platelet distribution width and non dipping pattern in children with essential hypertension |
| topic | Hypertension Children Non-dipping pattern Platelet distribution width Left ventricular hypertrophy |
| url | https://doi.org/10.1186/s12887-025-05420-2 |
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