Herpes simplex virus 1 glycoprotein C promotes virus penetration from endosomes during entry, independent of interaction with heparan sulfate

Herpes simplex virus 1 glycoprotein C promotes virus penetration from endosomes during entry, independent of interaction with heparan sulfate

Herpes simplex virus 1 (HSV-1) gC is a multi-functional glycoprotein present in the viral envelope and on the surface of infected cells. Virion gC, and to a lesser extent the fusion protein gB, interacts with host heparan sulfate to mediate HSV-1 attachment to the cell surface. Virion gC selectively...

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Bibliographic Details
Main Authors: Seth M. Schneider, Giulia Tebaldi, Katrina A. Gianopulos, Darin J. Weed, Suzanne M. Pritchard, Chloe Leach, Anthony V. Nicola
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Microbiology
Subjects:
herpes simplex virus
fusion
glycoprotein C
heparan sulfate
virus entry
virus penetration
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1549349/full
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