A Paratransgenic Strategy for the Control of Chagas Disease
Chagas disease results from infection with the parasite Trypanosoma cruzi. This disease remains a significant cause of morbidity and mortality in central and south America. Chagas disease now exists and is detected worldwide because of human migration. Control of Chagas disease has relied mainly on...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Psyche: A Journal of Entomology |
| Online Access: | http://dx.doi.org/10.1155/2012/178930 |
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| _version_ | 1849304639632048128 |
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| author | Ivy Hurwitz Annabeth Fieck Nichole Klein Christo Jose Angray Kang Ravi Durvasula |
| author_facet | Ivy Hurwitz Annabeth Fieck Nichole Klein Christo Jose Angray Kang Ravi Durvasula |
| author_sort | Ivy Hurwitz |
| collection | DOAJ |
| description | Chagas disease results from infection with the parasite Trypanosoma cruzi. This disease remains a significant cause of morbidity and mortality in central and south America. Chagas disease now exists and is detected worldwide because of human migration. Control of Chagas disease has relied mainly on vector eradication however, the development of insect resistance to pesticides, coupled with cost and adverse health effects of insecticide treatments, has prompted our group to investigate novel methods of transmission control. Our laboratory has been instrumental in the development of the paratransgenic strategy to control vectorial transmission of T. cruzi. In this paper, we discuss various components of the paratransgenic approach. Specifically, we describe classes of molecules that can serve as effectors, including antimicrobial peptides, endoglucanases, and highly specific single chain antibodies that target surface glycoprotein tags on the surface of T. cruzi. Furthermore, we address evolving concepts related to field dispersal of engineered bacteria as part of the paratransgenic control strategy and attendant risk assessment evaluation. |
| format | Article |
| id | doaj-art-41675b044a2c4cf4b292e8b0ad69d6d7 |
| institution | Kabale University |
| issn | 0033-2615 1687-7438 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Psyche: A Journal of Entomology |
| spelling | doaj-art-41675b044a2c4cf4b292e8b0ad69d6d72025-08-20T03:55:40ZengWileyPsyche: A Journal of Entomology0033-26151687-74382012-01-01201210.1155/2012/178930178930A Paratransgenic Strategy for the Control of Chagas DiseaseIvy Hurwitz0Annabeth Fieck1Nichole Klein2Christo Jose3Angray Kang4Ravi Durvasula5Department of Internal Medicine, Center for Global Health, Health Science Center, University of New Mexico and New Mexico VA Health Care System, Albuquerque, NM 87131, USADepartment of Internal Medicine, Center for Global Health, Health Science Center, University of New Mexico and New Mexico VA Health Care System, Albuquerque, NM 87131, USADepartment of Internal Medicine, Center for Global Health, Health Science Center, University of New Mexico and New Mexico VA Health Care System, Albuquerque, NM 87131, USADepartment of Internal Medicine, Center for Global Health, Health Science Center, University of New Mexico and New Mexico VA Health Care System, Albuquerque, NM 87131, USABarts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 4AT, UKDepartment of Internal Medicine, Center for Global Health, Health Science Center, University of New Mexico and New Mexico VA Health Care System, Albuquerque, NM 87131, USAChagas disease results from infection with the parasite Trypanosoma cruzi. This disease remains a significant cause of morbidity and mortality in central and south America. Chagas disease now exists and is detected worldwide because of human migration. Control of Chagas disease has relied mainly on vector eradication however, the development of insect resistance to pesticides, coupled with cost and adverse health effects of insecticide treatments, has prompted our group to investigate novel methods of transmission control. Our laboratory has been instrumental in the development of the paratransgenic strategy to control vectorial transmission of T. cruzi. In this paper, we discuss various components of the paratransgenic approach. Specifically, we describe classes of molecules that can serve as effectors, including antimicrobial peptides, endoglucanases, and highly specific single chain antibodies that target surface glycoprotein tags on the surface of T. cruzi. Furthermore, we address evolving concepts related to field dispersal of engineered bacteria as part of the paratransgenic control strategy and attendant risk assessment evaluation.http://dx.doi.org/10.1155/2012/178930 |
| spellingShingle | Ivy Hurwitz Annabeth Fieck Nichole Klein Christo Jose Angray Kang Ravi Durvasula A Paratransgenic Strategy for the Control of Chagas Disease Psyche: A Journal of Entomology |
| title | A Paratransgenic Strategy for the Control of Chagas Disease |
| title_full | A Paratransgenic Strategy for the Control of Chagas Disease |
| title_fullStr | A Paratransgenic Strategy for the Control of Chagas Disease |
| title_full_unstemmed | A Paratransgenic Strategy for the Control of Chagas Disease |
| title_short | A Paratransgenic Strategy for the Control of Chagas Disease |
| title_sort | paratransgenic strategy for the control of chagas disease |
| url | http://dx.doi.org/10.1155/2012/178930 |
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