Telomere length and incident atrial fibrillation - data of the PREVEND cohort.
<h4>Background</h4>The incidence of atrial fibrillation (AF) increases with age. Telomere length is considered a marker of biological ageing. We investigated the association between leukocyte telomere length and incident AF in the Dutch Prevention of Renal and Vascular End-stage Disease...
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Public Library of Science (PLoS)
2017-01-01
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| author | Joylene E Siland Bastiaan Geelhoed Isabelle C van Gelder Pim van der Harst Michiel Rienstra |
| author_facet | Joylene E Siland Bastiaan Geelhoed Isabelle C van Gelder Pim van der Harst Michiel Rienstra |
| author_sort | Joylene E Siland |
| collection | DOAJ |
| description | <h4>Background</h4>The incidence of atrial fibrillation (AF) increases with age. Telomere length is considered a marker of biological ageing. We investigated the association between leukocyte telomere length and incident AF in the Dutch Prevention of Renal and Vascular End-stage Disease (PREVEND) study.<h4>Methods</h4>We included 7775 individuals without prevalent AF, and with leukocyte telomere length measured. Mean telomere length was determined by a monochrome multiplex quantitative polymerase chain reaction-based assay.<h4>Results</h4>Mean age of our cohort was 49±13 years, and 50% were men. During a mean follow-up of 11.4±2.9 years incident AF was detected in 367 (4.7%) individuals. Telomere length was shorter in individuals developing incident AF compared to those without AF (p = 0.013). Incident AF was inversely related to the telomere length. In the quartile with the longest telomere length 68 (3.5%) individuals developed AF, in the shortest telomere length quartile 100 (5.1%) individuals (p = 0.032). Telomere length was associated with incident AF in the second shortest telomere length quartile using the longest telomere length quartile as reference (hazard ratio 1.64; 95% CI 1.02-2.66; p = 0.043). After including age or AF risk factors, the relation between telomere length and incident AF was no longer significant. We found a significant interaction of age, male sex, systolic blood pressure, BMI, heart failure, and myocardial infarction with telomere length for the association with incident AF.<h4>Conclusions</h4>We found that shorter leukocyte telomere length is not independently associated with incident AF in a community-based cohort. |
| format | Article |
| id | doaj-art-415e8a181c834c44ab294620bbf2cd52 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-415e8a181c834c44ab294620bbf2cd522025-08-20T02:45:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017154510.1371/journal.pone.0171545Telomere length and incident atrial fibrillation - data of the PREVEND cohort.Joylene E SilandBastiaan GeelhoedIsabelle C van GelderPim van der HarstMichiel Rienstra<h4>Background</h4>The incidence of atrial fibrillation (AF) increases with age. Telomere length is considered a marker of biological ageing. We investigated the association between leukocyte telomere length and incident AF in the Dutch Prevention of Renal and Vascular End-stage Disease (PREVEND) study.<h4>Methods</h4>We included 7775 individuals without prevalent AF, and with leukocyte telomere length measured. Mean telomere length was determined by a monochrome multiplex quantitative polymerase chain reaction-based assay.<h4>Results</h4>Mean age of our cohort was 49±13 years, and 50% were men. During a mean follow-up of 11.4±2.9 years incident AF was detected in 367 (4.7%) individuals. Telomere length was shorter in individuals developing incident AF compared to those without AF (p = 0.013). Incident AF was inversely related to the telomere length. In the quartile with the longest telomere length 68 (3.5%) individuals developed AF, in the shortest telomere length quartile 100 (5.1%) individuals (p = 0.032). Telomere length was associated with incident AF in the second shortest telomere length quartile using the longest telomere length quartile as reference (hazard ratio 1.64; 95% CI 1.02-2.66; p = 0.043). After including age or AF risk factors, the relation between telomere length and incident AF was no longer significant. We found a significant interaction of age, male sex, systolic blood pressure, BMI, heart failure, and myocardial infarction with telomere length for the association with incident AF.<h4>Conclusions</h4>We found that shorter leukocyte telomere length is not independently associated with incident AF in a community-based cohort.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171545&type=printable |
| spellingShingle | Joylene E Siland Bastiaan Geelhoed Isabelle C van Gelder Pim van der Harst Michiel Rienstra Telomere length and incident atrial fibrillation - data of the PREVEND cohort. PLoS ONE |
| title | Telomere length and incident atrial fibrillation - data of the PREVEND cohort. |
| title_full | Telomere length and incident atrial fibrillation - data of the PREVEND cohort. |
| title_fullStr | Telomere length and incident atrial fibrillation - data of the PREVEND cohort. |
| title_full_unstemmed | Telomere length and incident atrial fibrillation - data of the PREVEND cohort. |
| title_short | Telomere length and incident atrial fibrillation - data of the PREVEND cohort. |
| title_sort | telomere length and incident atrial fibrillation data of the prevend cohort |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171545&type=printable |
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