Mineralocorticoid receptor antagonists reduce inflammatory signaling independent of myofiber mineralocorticoid receptor

Mineralocorticoid receptor antagonists reduce inflammatory signaling independent of myofiber mineralocorticoid receptor

Chronic inflammation is a feature of Duchenne muscular dystrophy (DMD), a degenerative striated muscle disease. Mineralocorticoid receptor (MR) antagonists (MRAs) have demonstrated clinical benefit on later onset DMD cardiomyopathy, and preclinical studies in mouse models have demonstrated efficacy...

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Bibliographic Details
Main Authors: Jeovanna Lowe, Arden B. Piepho, Chetan K. Gomatam, Peyton Debell, Megan N. Ballinger, Jill A. Rafael-Fortney
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Endocrine and Metabolic Science
Subjects:
Inflammation
Muscular dystrophy
mdx
Mineralocorticoid receptor
Myeloid
Online Access:http://www.sciencedirect.com/science/article/pii/S2666396125000524
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