EVALUATION OF THE GENETIC RISKOMETER COMPONENTS KIF6, PALLD, SNX19, MYH15, VAMP8 FOR ISCHEMIC HEART DISEASE WITH SUDDEN CARDIAC DEATH
Aim. The study of mononucleotide polymorphisms associations rs20455 gene KIF6, rs7439293 gene PALLD, rs2298566 gene SNX19, rs3900940 gene MYH15, rs1010 gene VAMP8, included into the Riskometer of ischemic heart disease of the Celera Corporation (USA), in sudden cardiac death.Material and methods. To...
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«FIRMA «SILICEA» LLC
2015-10-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/257 |
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| author | V. N. Мaksimov A. A. Ivanova P. S. Orlov S. V. Savchenko M. I. Voevoda |
| author_facet | V. N. Мaksimov A. A. Ivanova P. S. Orlov S. V. Savchenko M. I. Voevoda |
| author_sort | V. N. Мaksimov |
| collection | DOAJ |
| description | Aim. The study of mononucleotide polymorphisms associations rs20455 gene KIF6, rs7439293 gene PALLD, rs2298566 gene SNX19, rs3900940 gene MYH15, rs1010 gene VAMP8, included into the Riskometer of ischemic heart disease of the Celera Corporation (USA), in sudden cardiac death.Material and methods. To the study the group of persons included, died from sudden cardiac death, according to the WHO criteria (n=352, mean age — 53,3±8,9 y.), control group from matched by age and gender from DNA bank of HAPIEE, MONICA studies (n=381, mean age — 53,1±8,3 y.), adolescents group (n=296, mean age — 15,6±0,9 y.). DNA extracted via the phenol-chloroform extraction from myocardium of the dyed due to sudden cardiac death, and from venous blood of controls. Genotyping performed with Real-time PCR method using the Taq-Mancatheters technology (Applied Biosystems).Results. The prevalence of alleles rs7439293 gene PALLD, rs2298566 gene SNX19, rs3900940 gene MYH15 did not statistically significantly differ among the groups. In those died suddenly older than 50 years, there was significant decrease of carriers of GG polymorphism rs20455 gene KIF6 (9,0%) comparing to the controls (17,8%) (р=0,009, OR=0,456, 95% CI 0,256-0,810). In men older 50, died suddenly, there was significant decrease of the carriers of genotype СС (8,0%) (р=0,002, OR=0,328, 95% CI 0,159-0,678) and increase of СТ genotype (49,6%) (р=0,025, OR=1,729, 95% CI 1,084-2,758) polymorphism rs1010 gene VAMP8 comparing to the controls (21,0%, 36,3%, respectively). Conclusion. Polymorphisms rs20455 gene KIF6 and rs1010 gene VAMP8 are associated with sudden cardiac death. |
| format | Article |
| id | doaj-art-415a7b27a94a4d2caab1767ca820e869 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2015-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
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| series | Российский кардиологический журнал |
| spelling | doaj-art-415a7b27a94a4d2caab1767ca820e8692025-08-20T02:59:37Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202015-10-01010121810.15829/1560-4071-2015-10-12-18257EVALUATION OF THE GENETIC RISKOMETER COMPONENTS KIF6, PALLD, SNX19, MYH15, VAMP8 FOR ISCHEMIC HEART DISEASE WITH SUDDEN CARDIAC DEATHV. N. Мaksimov0A. A. Ivanova1P. S. Orlov2S. V. Savchenko3M. I. Voevoda4Scientific-Research Institute of Therapy and Prevention Medicine of SD RAS, Novosibirsk; Novosibirsk State Medical UniversityScientific-Research Institute of Therapy and Prevention Medicine of SD RAS, NovosibirskScientific-Research Institute of Therapy and Prevention Medicine of SD RAS, Novosibirsk; Institute of Cytology and Genetics of Siberian RAS Department, NovosibirskNovosibirsk State Medical University; Novosibirsk Regional Bureau of Forensic Medicine, NovosibirskScientific-Research Institute of Therapy and Prevention Medicine of SD RAS, Novosibirsk; Institute of Cytology and Genetics of Siberian RAS Department, NovosibirskAim. The study of mononucleotide polymorphisms associations rs20455 gene KIF6, rs7439293 gene PALLD, rs2298566 gene SNX19, rs3900940 gene MYH15, rs1010 gene VAMP8, included into the Riskometer of ischemic heart disease of the Celera Corporation (USA), in sudden cardiac death.Material and methods. To the study the group of persons included, died from sudden cardiac death, according to the WHO criteria (n=352, mean age — 53,3±8,9 y.), control group from matched by age and gender from DNA bank of HAPIEE, MONICA studies (n=381, mean age — 53,1±8,3 y.), adolescents group (n=296, mean age — 15,6±0,9 y.). DNA extracted via the phenol-chloroform extraction from myocardium of the dyed due to sudden cardiac death, and from venous blood of controls. Genotyping performed with Real-time PCR method using the Taq-Mancatheters technology (Applied Biosystems).Results. The prevalence of alleles rs7439293 gene PALLD, rs2298566 gene SNX19, rs3900940 gene MYH15 did not statistically significantly differ among the groups. In those died suddenly older than 50 years, there was significant decrease of carriers of GG polymorphism rs20455 gene KIF6 (9,0%) comparing to the controls (17,8%) (р=0,009, OR=0,456, 95% CI 0,256-0,810). In men older 50, died suddenly, there was significant decrease of the carriers of genotype СС (8,0%) (р=0,002, OR=0,328, 95% CI 0,159-0,678) and increase of СТ genotype (49,6%) (р=0,025, OR=1,729, 95% CI 1,084-2,758) polymorphism rs1010 gene VAMP8 comparing to the controls (21,0%, 36,3%, respectively). Conclusion. Polymorphisms rs20455 gene KIF6 and rs1010 gene VAMP8 are associated with sudden cardiac death.https://russjcardiol.elpub.ru/jour/article/view/257sudden cardiac deathmononucleotide polymorphismriskometergene rs20455kif6rs7439293palldrs2298566snx19rs3900940myh15rs1010vamp8 |
| spellingShingle | V. N. Мaksimov A. A. Ivanova P. S. Orlov S. V. Savchenko M. I. Voevoda EVALUATION OF THE GENETIC RISKOMETER COMPONENTS KIF6, PALLD, SNX19, MYH15, VAMP8 FOR ISCHEMIC HEART DISEASE WITH SUDDEN CARDIAC DEATH Российский кардиологический журнал sudden cardiac death mononucleotide polymorphism riskometer gene rs20455 kif6 rs7439293 palld rs2298566 snx19 rs3900940 myh15 rs1010 vamp8 |
| title | EVALUATION OF THE GENETIC RISKOMETER COMPONENTS KIF6, PALLD, SNX19, MYH15, VAMP8 FOR ISCHEMIC HEART DISEASE WITH SUDDEN CARDIAC DEATH |
| title_full | EVALUATION OF THE GENETIC RISKOMETER COMPONENTS KIF6, PALLD, SNX19, MYH15, VAMP8 FOR ISCHEMIC HEART DISEASE WITH SUDDEN CARDIAC DEATH |
| title_fullStr | EVALUATION OF THE GENETIC RISKOMETER COMPONENTS KIF6, PALLD, SNX19, MYH15, VAMP8 FOR ISCHEMIC HEART DISEASE WITH SUDDEN CARDIAC DEATH |
| title_full_unstemmed | EVALUATION OF THE GENETIC RISKOMETER COMPONENTS KIF6, PALLD, SNX19, MYH15, VAMP8 FOR ISCHEMIC HEART DISEASE WITH SUDDEN CARDIAC DEATH |
| title_short | EVALUATION OF THE GENETIC RISKOMETER COMPONENTS KIF6, PALLD, SNX19, MYH15, VAMP8 FOR ISCHEMIC HEART DISEASE WITH SUDDEN CARDIAC DEATH |
| title_sort | evaluation of the genetic riskometer components kif6 palld snx19 myh15 vamp8 for ischemic heart disease with sudden cardiac death |
| topic | sudden cardiac death mononucleotide polymorphism riskometer gene rs20455 kif6 rs7439293 palld rs2298566 snx19 rs3900940 myh15 rs1010 vamp8 |
| url | https://russjcardiol.elpub.ru/jour/article/view/257 |
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