Bone marrow lesions in osteoarthritis: Characterising genetic and histological changes to understand disease pathophysiology
Osteoarthritis (OA) is a chronic debilitating condition that affects the whole joint. There are several sources of pain in OA that include the synovium, bone, including osteophytes and more recently bone marrow lesions (BML) that correlate with pain. Recent studies have shown that the bone compartme...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913124000980 |
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| author | Nidhi Sofat Franklyn Arron Howe |
| author_facet | Nidhi Sofat Franklyn Arron Howe |
| author_sort | Nidhi Sofat |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a chronic debilitating condition that affects the whole joint. There are several sources of pain in OA that include the synovium, bone, including osteophytes and more recently bone marrow lesions (BML) that correlate with pain. Recent studies have shown that the bone compartment contributes to pain in OA through the development of OA-BMLs which are richly innervated and demonstrate angiogenesis. The synovium is also innervated in OA tissue and is another distinct source of pain, with imaging and genetic studies supporting the observation that synovitis is an important component of pain in OA. Previous studies using magnetic resonance imaging (MRI) have shown that bone marrow lesions (BMLs), observed as high intensity signal on T2 fat-suppressed imaging sequences, are commonly found in OA and are associated with progression of pain symptoms. Recent studies have described the genetic signature of BMLs and the characteristic histological changes of BML tissue. In this narrative review we describe the recent developments in the discovery of the gene expression profiles identified from BMLs. We also review the recently characterised histological changes from BMLs in large weight-bearing joints including the knee and hip. Finally, we discuss the implications of new genetic and histological findings in BML in the context of new developments for pharmacological therapies in OA. |
| format | Article |
| id | doaj-art-4158dbe8fd0b426b9d06f465a0074ef9 |
| institution | OA Journals |
| issn | 2665-9131 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-4158dbe8fd0b426b9d06f465a0074ef92025-08-20T02:05:28ZengElsevierOsteoarthritis and Cartilage Open2665-91312024-12-016410053110.1016/j.ocarto.2024.100531Bone marrow lesions in osteoarthritis: Characterising genetic and histological changes to understand disease pathophysiologyNidhi Sofat0Franklyn Arron Howe1Institute for Infection and Immunity, School of Health & Medical Sciences, City St Georgeʼs, University of London, London, UK; Department of Rheumatology, St George’s University Hospitals NHS Foundation Trust, UK; Corresponding author. Institute for Infection and Immunity, St George’s University of London, Cranmer Terrace, London, SW17 ORE, UK.Neuroscience & Cell Biology Research Institute, School of Health & Medical Sciences, City St Georgeʼs, University of London, London, UKOsteoarthritis (OA) is a chronic debilitating condition that affects the whole joint. There are several sources of pain in OA that include the synovium, bone, including osteophytes and more recently bone marrow lesions (BML) that correlate with pain. Recent studies have shown that the bone compartment contributes to pain in OA through the development of OA-BMLs which are richly innervated and demonstrate angiogenesis. The synovium is also innervated in OA tissue and is another distinct source of pain, with imaging and genetic studies supporting the observation that synovitis is an important component of pain in OA. Previous studies using magnetic resonance imaging (MRI) have shown that bone marrow lesions (BMLs), observed as high intensity signal on T2 fat-suppressed imaging sequences, are commonly found in OA and are associated with progression of pain symptoms. Recent studies have described the genetic signature of BMLs and the characteristic histological changes of BML tissue. In this narrative review we describe the recent developments in the discovery of the gene expression profiles identified from BMLs. We also review the recently characterised histological changes from BMLs in large weight-bearing joints including the knee and hip. Finally, we discuss the implications of new genetic and histological findings in BML in the context of new developments for pharmacological therapies in OA.http://www.sciencedirect.com/science/article/pii/S2665913124000980OsteoarthritisBone marrow lesionsOsteoarthritis bone scoreGenetics |
| spellingShingle | Nidhi Sofat Franklyn Arron Howe Bone marrow lesions in osteoarthritis: Characterising genetic and histological changes to understand disease pathophysiology Osteoarthritis and Cartilage Open Osteoarthritis Bone marrow lesions Osteoarthritis bone score Genetics |
| title | Bone marrow lesions in osteoarthritis: Characterising genetic and histological changes to understand disease pathophysiology |
| title_full | Bone marrow lesions in osteoarthritis: Characterising genetic and histological changes to understand disease pathophysiology |
| title_fullStr | Bone marrow lesions in osteoarthritis: Characterising genetic and histological changes to understand disease pathophysiology |
| title_full_unstemmed | Bone marrow lesions in osteoarthritis: Characterising genetic and histological changes to understand disease pathophysiology |
| title_short | Bone marrow lesions in osteoarthritis: Characterising genetic and histological changes to understand disease pathophysiology |
| title_sort | bone marrow lesions in osteoarthritis characterising genetic and histological changes to understand disease pathophysiology |
| topic | Osteoarthritis Bone marrow lesions Osteoarthritis bone score Genetics |
| url | http://www.sciencedirect.com/science/article/pii/S2665913124000980 |
| work_keys_str_mv | AT nidhisofat bonemarrowlesionsinosteoarthritischaracterisinggeneticandhistologicalchangestounderstanddiseasepathophysiology AT franklynarronhowe bonemarrowlesionsinosteoarthritischaracterisinggeneticandhistologicalchangestounderstanddiseasepathophysiology |