Pseudohypoxia-Stabilized HIF2α Transcriptionally Inhibits <i>MNRR1</i>, a Druggable Target in MELAS

Pseudohypoxia-Stabilized HIF2α Transcriptionally Inhibits <i>MNRR1</i>, a Druggable Target in MELAS

The mitochondrial regulator MNRR1 is reduced in several pathologies, including the mitochondrial heteroplasmic disease MELAS, and genetic restoration of its level normalizes the pathological phenotype. Here, we investigate the upstream mechanism that reduces MNRR1 levels. We have identified the hypo...

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Bibliographic Details
Main Authors: Neeraja Purandare, Vignesh Pasupathi, Yue Xi, Vikram Rajan, Caleb Vegh, Steven Firestine, Tamas Kozicz, Andrew M. Fribley, Lawrence I. Grossman, Siddhesh Aras
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
drug repurposing
heteroplasmy
hypoxia
Online Access:https://www.mdpi.com/2073-4409/14/14/1078
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