A case of rapidly progressing and poorly differentiated Ip‐type early‐stage colorectal adenocarcinoma
Abstract A 36‐year‐old woman visited our hospital with a chief complaint of bleeding during defecation. Colonoscopy revealed a 20‐mm pedunculated polyp in the sigmoid colon, which was en bloc resected under endoscopy. The histopathological diagnosis was adenoma cancer with a depth of invasion indica...
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | DEN Open |
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| Online Access: | https://doi.org/10.1002/deo2.181 |
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| author | Atsuko Tsubomoto Hiroshi Sashiyama Junichi Koike Yohei Morita Osamu Tsutsumi Yukihiro Hamahata |
| author_facet | Atsuko Tsubomoto Hiroshi Sashiyama Junichi Koike Yohei Morita Osamu Tsutsumi Yukihiro Hamahata |
| author_sort | Atsuko Tsubomoto |
| collection | DOAJ |
| description | Abstract A 36‐year‐old woman visited our hospital with a chief complaint of bleeding during defecation. Colonoscopy revealed a 20‐mm pedunculated polyp in the sigmoid colon, which was en bloc resected under endoscopy. The histopathological diagnosis was adenoma cancer with a depth of invasion indicating mucosal cancer, no lymphovascular invasion, and negative at the resection margin. The poorly differentiated adenocarcinoma component comprised approximately 5% of the tumor. Although there were no recurrence signs in the computed tomography scans obtained 4 months post polypectomy, the patient experienced aggressive lower back pain at 6 months post polypectomy. Local recurrence, peritoneal dissemination, and liver metastasis were confirmed. Finally, the patient died following a rapid and aggressive deterioration of her general condition. Histological examination of the local recurrence revealed a poorly differentiated adenocarcinoma (por2), with immunostaining revealing a high Ki67 positivity rate of 95%. Moreover, the poorly differentiated adenocarcinoma region of the resected polyp had a Ki67 positivity rate of 90%, which suggested that they were the same tumors. These findings suggested that the recurrence could have occurred through implantation. |
| format | Article |
| id | doaj-art-41549db28ea24c1392cf86fabbdee5ff |
| institution | DOAJ |
| issn | 2692-4609 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj-art-41549db28ea24c1392cf86fabbdee5ff2025-08-20T03:10:01ZengWileyDEN Open2692-46092023-04-0131n/an/a10.1002/deo2.181A case of rapidly progressing and poorly differentiated Ip‐type early‐stage colorectal adenocarcinomaAtsuko Tsubomoto0Hiroshi Sashiyama1Junichi Koike2Yohei Morita3Osamu Tsutsumi4Yukihiro Hamahata5Department of Colorectal Surgery Tsujinaka Hospital Kashiwanoha Chiba JapanDepartment of Colorectal Surgery Tsujinaka Hospital Kashiwanoha Chiba JapanDepartment of Colorectal Surgery Tsujinaka Hospital Kashiwanoha Chiba JapanDepartment of Colorectal Surgery Tsujinaka Hospital Kashiwanoha Chiba JapanDepartment of Colorectal Surgery Tsujinaka Hospital Kashiwanoha Chiba JapanDepartment of Colorectal Surgery Tsujinaka Hospital Kashiwanoha Chiba JapanAbstract A 36‐year‐old woman visited our hospital with a chief complaint of bleeding during defecation. Colonoscopy revealed a 20‐mm pedunculated polyp in the sigmoid colon, which was en bloc resected under endoscopy. The histopathological diagnosis was adenoma cancer with a depth of invasion indicating mucosal cancer, no lymphovascular invasion, and negative at the resection margin. The poorly differentiated adenocarcinoma component comprised approximately 5% of the tumor. Although there were no recurrence signs in the computed tomography scans obtained 4 months post polypectomy, the patient experienced aggressive lower back pain at 6 months post polypectomy. Local recurrence, peritoneal dissemination, and liver metastasis were confirmed. Finally, the patient died following a rapid and aggressive deterioration of her general condition. Histological examination of the local recurrence revealed a poorly differentiated adenocarcinoma (por2), with immunostaining revealing a high Ki67 positivity rate of 95%. Moreover, the poorly differentiated adenocarcinoma region of the resected polyp had a Ki67 positivity rate of 90%, which suggested that they were the same tumors. These findings suggested that the recurrence could have occurred through implantation.https://doi.org/10.1002/deo2.181early‐stage cancerimplantationIp‐typeKi67 antigenpoorly differentiated colorectal adenocarcinoma |
| spellingShingle | Atsuko Tsubomoto Hiroshi Sashiyama Junichi Koike Yohei Morita Osamu Tsutsumi Yukihiro Hamahata A case of rapidly progressing and poorly differentiated Ip‐type early‐stage colorectal adenocarcinoma DEN Open early‐stage cancer implantation Ip‐type Ki67 antigen poorly differentiated colorectal adenocarcinoma |
| title | A case of rapidly progressing and poorly differentiated Ip‐type early‐stage colorectal adenocarcinoma |
| title_full | A case of rapidly progressing and poorly differentiated Ip‐type early‐stage colorectal adenocarcinoma |
| title_fullStr | A case of rapidly progressing and poorly differentiated Ip‐type early‐stage colorectal adenocarcinoma |
| title_full_unstemmed | A case of rapidly progressing and poorly differentiated Ip‐type early‐stage colorectal adenocarcinoma |
| title_short | A case of rapidly progressing and poorly differentiated Ip‐type early‐stage colorectal adenocarcinoma |
| title_sort | case of rapidly progressing and poorly differentiated ip type early stage colorectal adenocarcinoma |
| topic | early‐stage cancer implantation Ip‐type Ki67 antigen poorly differentiated colorectal adenocarcinoma |
| url | https://doi.org/10.1002/deo2.181 |
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