Imipramine is an orally active drug against both antimony sensitive and resistant Leishmania donovani clinical isolates in experimental infection.

Imipramine is an orally active drug against both antimony sensitive and resistant Leishmania donovani clinical isolates in experimental infection.

<h4>Background</h4>In an endeavor to find an orally active and affordable antileishmanial drug, we tested the efficacy of a cationic amphiphilic drug, imipramine, commonly used for the treatment of depression in humans. The only available orally active antileishmanial drug is miltefosine...

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Bibliographic Details
Main Authors: Sandip Mukherjee, Budhaditya Mukherjee, Rupkatha Mukhopadhyay, Kshudiram Naskar, Shyam Sundar, Jean Claude Dujardin, Anjan Kumar Das, Syamal Roy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0001987&type=printable
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