Associations of levels of biochemical markers of chronic and acute inflammation, abdominal obesity and post-COVID syndrome in COVID-19 convalescents
Aim. To study the associations of abdominal obesity (AO), levels of biochemical markers of chronic and acute inflammation, and post-COVID syndrome (PCS) in coronavirus disease 2019 (COVID-19) convalescents.Material and methods. The cross-sectional observational study included 166 people aged 18-84...
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«SILICEA-POLIGRAF» LLC
2024-11-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/4131 |
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| author | A. A. Karaseva A. D. Afanaseva E. V. Garbuzova E. V. Kashtanova Ya. V. Polonskaya V. S. Shramko I. I. Logvinenko Yu. I. Ragino |
| author_facet | A. A. Karaseva A. D. Afanaseva E. V. Garbuzova E. V. Kashtanova Ya. V. Polonskaya V. S. Shramko I. I. Logvinenko Yu. I. Ragino |
| author_sort | A. A. Karaseva |
| collection | DOAJ |
| description | Aim. To study the associations of abdominal obesity (AO), levels of biochemical markers of chronic and acute inflammation, and post-COVID syndrome (PCS) in coronavirus disease 2019 (COVID-19) convalescents.Material and methods. The cross-sectional observational study included 166 people aged 18-84 (44,6% men) who were COVID-19 convalescents. In all patients, medical history and anthropometric data were collected. AO was defined as waist circumference >80 cm in women and >94 cm in men. In the blood serum, the concentrations of following biochemical markers of chronic and acute inflammation were determined by the enzyme immunoassay method: interferon alpha, interleukins (IL) 1 beta (IL-1β), IL-6, IL-8, monocyte chemoattractant protein-1 (MCP-1), insulin, C-peptide, high-sensitivity C-reactive protein (hsCRP).Results. COVID-19 convalescents with PCS and AO had significantly higher levels of IL-6 (3,13 [2,26;4,98] and 1,74 [1,10;3,04] pg/ml, p<0,0001, respectively) and hsCRP (3,83 [2,42;10,16] and 2,34 [0,70;5,79] mg/l, p=0,028, respectively) than without AO. Insulin and C-peptide demonstrated significant differences in COVID-19 convalescents with AO regardless of PCS. Multivariate logistic regression analysis showed that the odds of having AO in COVID-19 convalescents with PCS increased by 1,6 times with an increase in blood IL-6 by 1 pg/ml (odds ratio (OR) 1,581, 95% confidence interval (CI): 1,001-2,416; p=0,047) and by 1,2 times with an increase in blood insulin by 1 pg/ml (OR 1,168, 95% CI: 1,015-1,343; p=0,030). AO in men with PCS is associated with the concentration of IL-6 (OR 1,943, 95% CI: 1,018-3,709; p=0,044) and IL-1β (OR 0,591, 95% CI: 0,362-0,967; p=0,036). PCS in women with AO and cardiovascular diseases is associated with the level of MCP-1 (OR 0,991, 95% CI: 0,983-0,999; p=0,035).Conclusion. In COVID-19 convalescents with PCS, the AO probability is associated with an increase in blood IL-6 and insulin. In men, the AO probability is associated with an increase in IL-6 and a decrease in IL-1β. In women with AO and a history of cardiovascular diseases, PCS is associated with the level of MCP-1 in the blood. |
| format | Article |
| id | doaj-art-414854e27b9a494bbc836cdbb9c487fc |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2024-11-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
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| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-414854e27b9a494bbc836cdbb9c487fc2025-08-20T03:57:18Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252024-11-01231010.15829/1728-8800-2024-41313089Associations of levels of biochemical markers of chronic and acute inflammation, abdominal obesity and post-COVID syndrome in COVID-19 convalescentsA. A. Karaseva0A. D. Afanaseva1E. V. Garbuzova2E. V. Kashtanova3Ya. V. Polonskaya4V. S. Shramko5I. I. Logvinenko6Yu. I. Ragino7Research Institute for Therapy and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsResearch Institute for Therapy and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsResearch Institute for Therapy and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsResearch Institute for Therapy and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsResearch Institute for Therapy and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsResearch Institute for Therapy and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsResearch Institute for Therapy and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsResearch Institute for Therapy and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsAim. To study the associations of abdominal obesity (AO), levels of biochemical markers of chronic and acute inflammation, and post-COVID syndrome (PCS) in coronavirus disease 2019 (COVID-19) convalescents.Material and methods. The cross-sectional observational study included 166 people aged 18-84 (44,6% men) who were COVID-19 convalescents. In all patients, medical history and anthropometric data were collected. AO was defined as waist circumference >80 cm in women and >94 cm in men. In the blood serum, the concentrations of following biochemical markers of chronic and acute inflammation were determined by the enzyme immunoassay method: interferon alpha, interleukins (IL) 1 beta (IL-1β), IL-6, IL-8, monocyte chemoattractant protein-1 (MCP-1), insulin, C-peptide, high-sensitivity C-reactive protein (hsCRP).Results. COVID-19 convalescents with PCS and AO had significantly higher levels of IL-6 (3,13 [2,26;4,98] and 1,74 [1,10;3,04] pg/ml, p<0,0001, respectively) and hsCRP (3,83 [2,42;10,16] and 2,34 [0,70;5,79] mg/l, p=0,028, respectively) than without AO. Insulin and C-peptide demonstrated significant differences in COVID-19 convalescents with AO regardless of PCS. Multivariate logistic regression analysis showed that the odds of having AO in COVID-19 convalescents with PCS increased by 1,6 times with an increase in blood IL-6 by 1 pg/ml (odds ratio (OR) 1,581, 95% confidence interval (CI): 1,001-2,416; p=0,047) and by 1,2 times with an increase in blood insulin by 1 pg/ml (OR 1,168, 95% CI: 1,015-1,343; p=0,030). AO in men with PCS is associated with the concentration of IL-6 (OR 1,943, 95% CI: 1,018-3,709; p=0,044) and IL-1β (OR 0,591, 95% CI: 0,362-0,967; p=0,036). PCS in women with AO and cardiovascular diseases is associated with the level of MCP-1 (OR 0,991, 95% CI: 0,983-0,999; p=0,035).Conclusion. In COVID-19 convalescents with PCS, the AO probability is associated with an increase in blood IL-6 and insulin. In men, the AO probability is associated with an increase in IL-6 and a decrease in IL-1β. In women with AO and a history of cardiovascular diseases, PCS is associated with the level of MCP-1 in the blood.https://cardiovascular.elpub.ru/jour/article/view/4131post-covid syndromecovid-19 convalescentsabdominal obesityinsulininterleukin-6interleukin-1betamcp-1 |
| spellingShingle | A. A. Karaseva A. D. Afanaseva E. V. Garbuzova E. V. Kashtanova Ya. V. Polonskaya V. S. Shramko I. I. Logvinenko Yu. I. Ragino Associations of levels of biochemical markers of chronic and acute inflammation, abdominal obesity and post-COVID syndrome in COVID-19 convalescents Кардиоваскулярная терапия и профилактика post-covid syndrome covid-19 convalescents abdominal obesity insulin interleukin-6 interleukin-1beta mcp-1 |
| title | Associations of levels of biochemical markers of chronic and acute inflammation, abdominal obesity and post-COVID syndrome in COVID-19 convalescents |
| title_full | Associations of levels of biochemical markers of chronic and acute inflammation, abdominal obesity and post-COVID syndrome in COVID-19 convalescents |
| title_fullStr | Associations of levels of biochemical markers of chronic and acute inflammation, abdominal obesity and post-COVID syndrome in COVID-19 convalescents |
| title_full_unstemmed | Associations of levels of biochemical markers of chronic and acute inflammation, abdominal obesity and post-COVID syndrome in COVID-19 convalescents |
| title_short | Associations of levels of biochemical markers of chronic and acute inflammation, abdominal obesity and post-COVID syndrome in COVID-19 convalescents |
| title_sort | associations of levels of biochemical markers of chronic and acute inflammation abdominal obesity and post covid syndrome in covid 19 convalescents |
| topic | post-covid syndrome covid-19 convalescents abdominal obesity insulin interleukin-6 interleukin-1beta mcp-1 |
| url | https://cardiovascular.elpub.ru/jour/article/view/4131 |
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