Improving retinal vascular endothelial cell tropism through rational rAAV capsid design.

Improving retinal vascular endothelial cell tropism through rational rAAV capsid design.

Vascular endothelial cells (VEC) are essential for retinal homeostasis and their dysfunction underlies pathogenesis in diabetic retinopathy (DR) and exudative age-related macular degeneration (AMD). Studies have shown that recombinant adeno-associated virus (rAAV) vectors are effective at delivering...

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Bibliographic Details
Main Authors: Ramesh Periasamy, Dwani D Patel, Sanford L Boye, Shannon E Boye, Daniel M Lipinski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0285370&type=printable
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