Autoradiographic comparison between [11C]PiB and [18F]AZD4694 in human brain tissue

Autoradiographic comparison between [11C]PiB and [18F]AZD4694 in human brain tissue

Abstract Background Amyloid-β imaging through positron emission tomography (PET) has significantly transformed Alzheimer’s disease (AD) research. [11C]PiB has been widely used for imaging β-amyloid plaques due to its high affinity and selectivity for amyloid deposits. [18F]AZD4694 is a more recently...

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Main Authors: Antonio Aliaga, Joseph Therriault, Kely Quispialaya, Arturo Aliaga, Peter Kunach, Arthur C. Macedo, Robert Hopewell, Nesrine Rahmouni, Jean-Paul Soucy, Gassan Massarweh, Marie-Christine Guiot, Tevy Chan, Jesse Klostranec, Aida Mary Abreu Diaz, Andreia Rocha, Giovanna Carello-Collar, Luiza S. Machado, Marco Antônio De Bastiani, Débora Guerini de Souza, Diogo O. Souza, Aline R. Zimmer, Serge Gauthier, Tharick A. Pascoal, Eduardo R. Zimmer, Pedro Rosa-Neto
Format: Article
Language:English
Published: SpringerOpen 2025-04-01
Series:EJNMMI Research
Subjects:
Alzheimer’s disease
[11C]PiB
[18F]AZD4694 ([18F]NAV4694)
Autoradiography
Amyloid-PET tracer
Online Access:https://doi.org/10.1186/s13550-025-01216-8
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