Cryo-EM Structures and AlphaFold3 Models of Histamine Receptors Reveal Diverse Ligand Binding and G Protein Bias

Cryo-EM Structures and AlphaFold3 Models of Histamine Receptors Reveal Diverse Ligand Binding and G Protein Bias

<b>Background:</b> The four subtypes of G protein-coupled receptors (GPCRs) regulated by histamine play critical roles in various physiological and pathological processes, such as allergy, gastric acid secretion, cognitive and sleep disorders, and inflammation. Previous experimental stru...

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Bibliographic Details
Main Authors: Anqi Chen, Chenxi Su, Zisu Zhang, Haitao Zhang
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceuticals
Subjects:
histamine receptors
ligand-binding pocket
activation mechanism
G protein bias
cryo-EM
AlphaFold3
Online Access:https://www.mdpi.com/1424-8247/18/3/292
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