Effect of intrapartum azithromycin on early childhood gut mycobiota development: post hoc analysis of a double-blind randomized trial
Abstract Intrapartum azithromycin prophylaxis reduced maternal infections but showed no effect on neonatal sepsis and mortality. Although antibiotic exposure may indirectly alter the mycobiota (community of fungi that live in a given environment), there is no data available on how intrapartum azithr...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-62142-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849764291278798848 |
|---|---|
| author | Bakary Sanyang Magdalena B. Dabrowska Nelly Amenyogbe Bully Camara Nathalie Beloum Mariama Jammeh Dodou Bojang Jack Goodall Nuredin Mohammed Abdul Karim Sesay Anna Roca Thushan I. de Silva |
| author_facet | Bakary Sanyang Magdalena B. Dabrowska Nelly Amenyogbe Bully Camara Nathalie Beloum Mariama Jammeh Dodou Bojang Jack Goodall Nuredin Mohammed Abdul Karim Sesay Anna Roca Thushan I. de Silva |
| author_sort | Bakary Sanyang |
| collection | DOAJ |
| description | Abstract Intrapartum azithromycin prophylaxis reduced maternal infections but showed no effect on neonatal sepsis and mortality. Although antibiotic exposure may indirectly alter the mycobiota (community of fungi that live in a given environment), there is no data available on how intrapartum azithromycin impacts gut mycobiota development. We hereby assess the impact of intrapartum azithromycin on gut mycobiota development from birth to the age of three years, by ITS2 gene profiling of rectal samples from 102 healthy Gambian infants selected from a double-blind randomized placebo-controlled clinical trial (PregnAnZI-2 – ClinicalTrials.org NCT03199547). In the trial, women received 2 g oral azithromycin or placebo (1:1) during labour with the intension of assessing effect on neonatal sepsis or mortality. Secondary objectives included effects on bacterial carriage and resistance, puerperal infections, and infant growth. Our analysis show that season and parity were key factors that influenced gut mycobiota development. Intrapartum azithromycin increased the abundance of Candida orthopsilosis but only in the wet season and did not show different effects by sex of the child. These data suggest that season and parity can be key factors influencing gut mycobiota development and may inform strategies for a wider implementation of intrapartum azithromycin intervention. |
| format | Article |
| id | doaj-art-4144499e00264ad7950eab54b9e2d4ca |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-4144499e00264ad7950eab54b9e2d4ca2025-08-20T03:05:10ZengNature PortfolioNature Communications2041-17232025-08-0116111310.1038/s41467-025-62142-wEffect of intrapartum azithromycin on early childhood gut mycobiota development: post hoc analysis of a double-blind randomized trialBakary Sanyang0Magdalena B. Dabrowska1Nelly Amenyogbe2Bully Camara3Nathalie Beloum4Mariama Jammeh5Dodou Bojang6Jack Goodall7Nuredin Mohammed8Abdul Karim Sesay9Anna Roca10Thushan I. de Silva11Medical Research Council Unit The Gambia at The London School of Hygiene and Tropical MedicineDivision of Clinical Medicine, School of Medicine and Population Health, The University of SheffieldDepartment of Microbiology and Immunology, Canadian Centre for Vaccinology, Dalhousie UniversityMedical Research Council Unit The Gambia at The London School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at The London School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at The London School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at The London School of Hygiene and Tropical MedicineDivision of Clinical Medicine, School of Medicine and Population Health, The University of SheffieldMedical Research Council Unit The Gambia at The London School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at The London School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at The London School of Hygiene and Tropical MedicineMedical Research Council Unit The Gambia at The London School of Hygiene and Tropical MedicineAbstract Intrapartum azithromycin prophylaxis reduced maternal infections but showed no effect on neonatal sepsis and mortality. Although antibiotic exposure may indirectly alter the mycobiota (community of fungi that live in a given environment), there is no data available on how intrapartum azithromycin impacts gut mycobiota development. We hereby assess the impact of intrapartum azithromycin on gut mycobiota development from birth to the age of three years, by ITS2 gene profiling of rectal samples from 102 healthy Gambian infants selected from a double-blind randomized placebo-controlled clinical trial (PregnAnZI-2 – ClinicalTrials.org NCT03199547). In the trial, women received 2 g oral azithromycin or placebo (1:1) during labour with the intension of assessing effect on neonatal sepsis or mortality. Secondary objectives included effects on bacterial carriage and resistance, puerperal infections, and infant growth. Our analysis show that season and parity were key factors that influenced gut mycobiota development. Intrapartum azithromycin increased the abundance of Candida orthopsilosis but only in the wet season and did not show different effects by sex of the child. These data suggest that season and parity can be key factors influencing gut mycobiota development and may inform strategies for a wider implementation of intrapartum azithromycin intervention.https://doi.org/10.1038/s41467-025-62142-w |
| spellingShingle | Bakary Sanyang Magdalena B. Dabrowska Nelly Amenyogbe Bully Camara Nathalie Beloum Mariama Jammeh Dodou Bojang Jack Goodall Nuredin Mohammed Abdul Karim Sesay Anna Roca Thushan I. de Silva Effect of intrapartum azithromycin on early childhood gut mycobiota development: post hoc analysis of a double-blind randomized trial Nature Communications |
| title | Effect of intrapartum azithromycin on early childhood gut mycobiota development: post hoc analysis of a double-blind randomized trial |
| title_full | Effect of intrapartum azithromycin on early childhood gut mycobiota development: post hoc analysis of a double-blind randomized trial |
| title_fullStr | Effect of intrapartum azithromycin on early childhood gut mycobiota development: post hoc analysis of a double-blind randomized trial |
| title_full_unstemmed | Effect of intrapartum azithromycin on early childhood gut mycobiota development: post hoc analysis of a double-blind randomized trial |
| title_short | Effect of intrapartum azithromycin on early childhood gut mycobiota development: post hoc analysis of a double-blind randomized trial |
| title_sort | effect of intrapartum azithromycin on early childhood gut mycobiota development post hoc analysis of a double blind randomized trial |
| url | https://doi.org/10.1038/s41467-025-62142-w |
| work_keys_str_mv | AT bakarysanyang effectofintrapartumazithromycinonearlychildhoodgutmycobiotadevelopmentposthocanalysisofadoubleblindrandomizedtrial AT magdalenabdabrowska effectofintrapartumazithromycinonearlychildhoodgutmycobiotadevelopmentposthocanalysisofadoubleblindrandomizedtrial AT nellyamenyogbe effectofintrapartumazithromycinonearlychildhoodgutmycobiotadevelopmentposthocanalysisofadoubleblindrandomizedtrial AT bullycamara effectofintrapartumazithromycinonearlychildhoodgutmycobiotadevelopmentposthocanalysisofadoubleblindrandomizedtrial AT nathaliebeloum effectofintrapartumazithromycinonearlychildhoodgutmycobiotadevelopmentposthocanalysisofadoubleblindrandomizedtrial AT mariamajammeh effectofintrapartumazithromycinonearlychildhoodgutmycobiotadevelopmentposthocanalysisofadoubleblindrandomizedtrial AT dodoubojang effectofintrapartumazithromycinonearlychildhoodgutmycobiotadevelopmentposthocanalysisofadoubleblindrandomizedtrial AT jackgoodall effectofintrapartumazithromycinonearlychildhoodgutmycobiotadevelopmentposthocanalysisofadoubleblindrandomizedtrial AT nuredinmohammed effectofintrapartumazithromycinonearlychildhoodgutmycobiotadevelopmentposthocanalysisofadoubleblindrandomizedtrial AT abdulkarimsesay effectofintrapartumazithromycinonearlychildhoodgutmycobiotadevelopmentposthocanalysisofadoubleblindrandomizedtrial AT annaroca effectofintrapartumazithromycinonearlychildhoodgutmycobiotadevelopmentposthocanalysisofadoubleblindrandomizedtrial AT thushanidesilva effectofintrapartumazithromycinonearlychildhoodgutmycobiotadevelopmentposthocanalysisofadoubleblindrandomizedtrial |