Modeling the distribution and progression of motor ability among children with cerebral palsy: An analysis of three reference centile sets
Background: Reference centiles describing gross motor function in children with cerebral palsy (CP) are used in clinical and research settings to guide treatments and evaluate interventions. However, it is unknown how existing references generalize to populations in novel settings. Aims: The aim of...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Heliyon |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024166467 |
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| author | Rachel Sanderlin Charlotte Schluger Joe Wu Francis Ang Eusebio Amy L. Roberts Laura Prosser |
| author_facet | Rachel Sanderlin Charlotte Schluger Joe Wu Francis Ang Eusebio Amy L. Roberts Laura Prosser |
| author_sort | Rachel Sanderlin |
| collection | DOAJ |
| description | Background: Reference centiles describing gross motor function in children with cerebral palsy (CP) are used in clinical and research settings to guide treatments and evaluate interventions. However, it is unknown how existing references generalize to populations in novel settings. Aims: The aim of this study is to evaluate the cross-sectional and longitudinal performance of three reference centiles to describe the motor function of children with CP aged 2–12 years at a large urban US pediatric hospital through a retrospective observational study. Methods: and Procedures: We assessed cross-sectional performance by ranking our clinical population by quartile distributions described by the references. We assessed longitudinal performance by analyzing the distribution of prediction errors and correlations between predictions and observed scores. Outcomes and Results: For cross-sectional distribution, the reference centiles by Hanna more closely described our population than those by Duran. For longitudinal progression, prediction error was less than 6 GMFM points for most records at 24-, 12-, and 6-month time scales for all three sets of reference centiles, but higher at a 48-month time scale. Prediction errors increased at younger ages and higher motor ability. Conclusions and implications: Despite differences in cross-sectional performance, all three reference centiles achieved similar longitudinal performance and are sufficient for most clinical and research uses. Caution should be used when applying these curves to locations with different standards of care. |
| format | Article |
| id | doaj-art-4142e773a1d54bf3ab3ebdc2100c83fd |
| institution | OA Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-4142e773a1d54bf3ab3ebdc2100c83fd2025-08-20T02:38:11ZengElsevierHeliyon2405-84402024-12-011023e4061510.1016/j.heliyon.2024.e40615Modeling the distribution and progression of motor ability among children with cerebral palsy: An analysis of three reference centile setsRachel Sanderlin0Charlotte Schluger1Joe Wu2Francis Ang Eusebio3Amy L. Roberts4Laura Prosser5Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, USA; Corresponding author. Roberts Center for Pediatric Research, 15th Floor, 2716 South Street, Philadelphia, PA 19146, USA.Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, USADepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, USADivision of Rehabilitation Medicine, Children's Hospital of Philadelphia, Philadelphia, USADepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, USADivision of Rehabilitation Medicine, Children's Hospital of Philadelphia, Philadelphia, USA; Department of Pediatrics, University of Pennsylvania, Philadelphia, USABackground: Reference centiles describing gross motor function in children with cerebral palsy (CP) are used in clinical and research settings to guide treatments and evaluate interventions. However, it is unknown how existing references generalize to populations in novel settings. Aims: The aim of this study is to evaluate the cross-sectional and longitudinal performance of three reference centiles to describe the motor function of children with CP aged 2–12 years at a large urban US pediatric hospital through a retrospective observational study. Methods: and Procedures: We assessed cross-sectional performance by ranking our clinical population by quartile distributions described by the references. We assessed longitudinal performance by analyzing the distribution of prediction errors and correlations between predictions and observed scores. Outcomes and Results: For cross-sectional distribution, the reference centiles by Hanna more closely described our population than those by Duran. For longitudinal progression, prediction error was less than 6 GMFM points for most records at 24-, 12-, and 6-month time scales for all three sets of reference centiles, but higher at a 48-month time scale. Prediction errors increased at younger ages and higher motor ability. Conclusions and implications: Despite differences in cross-sectional performance, all three reference centiles achieved similar longitudinal performance and are sufficient for most clinical and research uses. Caution should be used when applying these curves to locations with different standards of care.http://www.sciencedirect.com/science/article/pii/S2405844024166467 |
| spellingShingle | Rachel Sanderlin Charlotte Schluger Joe Wu Francis Ang Eusebio Amy L. Roberts Laura Prosser Modeling the distribution and progression of motor ability among children with cerebral palsy: An analysis of three reference centile sets Heliyon |
| title | Modeling the distribution and progression of motor ability among children with cerebral palsy: An analysis of three reference centile sets |
| title_full | Modeling the distribution and progression of motor ability among children with cerebral palsy: An analysis of three reference centile sets |
| title_fullStr | Modeling the distribution and progression of motor ability among children with cerebral palsy: An analysis of three reference centile sets |
| title_full_unstemmed | Modeling the distribution and progression of motor ability among children with cerebral palsy: An analysis of three reference centile sets |
| title_short | Modeling the distribution and progression of motor ability among children with cerebral palsy: An analysis of three reference centile sets |
| title_sort | modeling the distribution and progression of motor ability among children with cerebral palsy an analysis of three reference centile sets |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024166467 |
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