Novel Potent and Selective Dopamine D4 Receptor Piperidine Antagonists as Potential Alternatives for the Treatment of Glioblastoma

<b>Background/Objectives</b>: D4R antagonists have recently been suggested as potential therapeutic alternatives to the standard treatments of glioblastoma (GBM). In this study, new piperidine-based ligands, analogs of the potent and selective D4R compounds 77-LH-28-1 (<b>7</b&g...

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Bibliographic Details
Main Authors:	Federica Matteucci, Pegi Pavletić, Alessandro Bonifazi, Rian Garland, Hideaki Yano, Consuelo Amantini, Laura Zeppa, Emanuela Sabato, Giulio Vistoli, Valerio Mammoli, Loredana Cappellacci, Fabio Del Bello, Gianfabio Giorgioni, Riccardo Petrelli, Alessia Piergentili, Wilma Quaglia, Alessandro Piergentili
Format:	Article
Language:	English
Published:	MDPI AG 2025-05-01
Series:	Pharmaceuticals
Subjects:	dopamine D4 receptors potent and selective D4R antagonists 4-butyl- and 4-benzyl-piperidines docking studies glioblastoma
Online Access:	https://www.mdpi.com/1424-8247/18/5/739
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Novel Potent and Selective Dopamine D4 Receptor Piperidine Antagonists as Potential Alternatives for the Treatment of Glioblastoma

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