Tumour Heterogeneity and Disease Infiltration as Paradigms of Glioblastoma Treatment Resistance
Isocitrate dehydrogenase wild-type glioblastoma, a Grade 4 malignant brain neoplasm, remains resistant to multimodal treatment, with a median survival of 16 months from diagnosis with no geographical bias. Despite increasing appreciation of intra-tumour genotypic variation and stem cell plasticity,...
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MDPI AG
2024-10-01
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| Online Access: | https://www.mdpi.com/2673-7523/4/4/24 |
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| author | Pulkit Malhotra Ruman Rahman |
| author_facet | Pulkit Malhotra Ruman Rahman |
| author_sort | Pulkit Malhotra |
| collection | DOAJ |
| description | Isocitrate dehydrogenase wild-type glioblastoma, a Grade 4 malignant brain neoplasm, remains resistant to multimodal treatment, with a median survival of 16 months from diagnosis with no geographical bias. Despite increasing appreciation of intra-tumour genotypic variation and stem cell plasticity, such knowledge has yet to translate to efficacious molecular targeted therapies in this post-genomic era. Critically, the manifestation of molecular heterogeneity and stem cell biological process within clinically relevant infiltrative disease is little understood. Here, we review the interactions between neural plasticity, intra-tumour heterogeneity and residual infiltrative disease, and we draw upon antibiotic resistance as an insightful analogy to further explain tumour heterogeneity. |
| format | Article |
| id | doaj-art-413fa90d92ee456483d1d74e1fdb984b |
| institution | Kabale University |
| issn | 2673-7523 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Onco |
| spelling | doaj-art-413fa90d92ee456483d1d74e1fdb984b2024-12-27T14:44:43ZengMDPI AGOnco2673-75232024-10-014434935810.3390/onco4040024Tumour Heterogeneity and Disease Infiltration as Paradigms of Glioblastoma Treatment ResistancePulkit Malhotra0Ruman Rahman1School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UKSchool of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UKIsocitrate dehydrogenase wild-type glioblastoma, a Grade 4 malignant brain neoplasm, remains resistant to multimodal treatment, with a median survival of 16 months from diagnosis with no geographical bias. Despite increasing appreciation of intra-tumour genotypic variation and stem cell plasticity, such knowledge has yet to translate to efficacious molecular targeted therapies in this post-genomic era. Critically, the manifestation of molecular heterogeneity and stem cell biological process within clinically relevant infiltrative disease is little understood. Here, we review the interactions between neural plasticity, intra-tumour heterogeneity and residual infiltrative disease, and we draw upon antibiotic resistance as an insightful analogy to further explain tumour heterogeneity.https://www.mdpi.com/2673-7523/4/4/24glioblastomastem cellplasticityintra-tumour heterogeneityantibiotic resistance |
| spellingShingle | Pulkit Malhotra Ruman Rahman Tumour Heterogeneity and Disease Infiltration as Paradigms of Glioblastoma Treatment Resistance Onco glioblastoma stem cell plasticity intra-tumour heterogeneity antibiotic resistance |
| title | Tumour Heterogeneity and Disease Infiltration as Paradigms of Glioblastoma Treatment Resistance |
| title_full | Tumour Heterogeneity and Disease Infiltration as Paradigms of Glioblastoma Treatment Resistance |
| title_fullStr | Tumour Heterogeneity and Disease Infiltration as Paradigms of Glioblastoma Treatment Resistance |
| title_full_unstemmed | Tumour Heterogeneity and Disease Infiltration as Paradigms of Glioblastoma Treatment Resistance |
| title_short | Tumour Heterogeneity and Disease Infiltration as Paradigms of Glioblastoma Treatment Resistance |
| title_sort | tumour heterogeneity and disease infiltration as paradigms of glioblastoma treatment resistance |
| topic | glioblastoma stem cell plasticity intra-tumour heterogeneity antibiotic resistance |
| url | https://www.mdpi.com/2673-7523/4/4/24 |
| work_keys_str_mv | AT pulkitmalhotra tumourheterogeneityanddiseaseinfiltrationasparadigmsofglioblastomatreatmentresistance AT rumanrahman tumourheterogeneityanddiseaseinfiltrationasparadigmsofglioblastomatreatmentresistance |