Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH.

Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH.

<h4>Background</h4>Tuberculosis (TB) is a disease which kills two million people every year and infects approximately over one-third of the world's population. The difficulty in managing tuberculosis is the prolonged treatment duration, the emergence of drug resistance and co-infect...

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Main Authors: Qosay Al-Balas, Nahoum G Anthony, Bilal Al-Jaidi, Amani Alnimr, Grainne Abbott, Alistair K Brown, Rebecca C Taylor, Gurdyal S Besra, Timothy D McHugh, Stephen H Gillespie, Blair F Johnston, Simon P Mackay, Geoffrey D Coxon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005617&type=printable
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