Enhanced integrated therapy for breast cancer employing Honokiol-loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low-dose metformin
Breast cancer remains a significant global health challenge, emphasizing the pressing need for innovative therapeutic approaches. Our thorough research investigates the potential of mesoporous polydopamine nanoparticles (MPDA) as a targeted treatment for breast cancer. Meticulously crafted, these na...
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| Format: | Article |
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AIP Publishing LLC
2025-03-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/5.0256571 |
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| author | Qianqian Du Qianfan Zhang Jialing Li Xiaofei Wang Xiangyu Gao Guangyuan Tan Qian Feng Jigang Li Yanchun Meng Yongsheng Yu |
| author_facet | Qianqian Du Qianfan Zhang Jialing Li Xiaofei Wang Xiangyu Gao Guangyuan Tan Qian Feng Jigang Li Yanchun Meng Yongsheng Yu |
| author_sort | Qianqian Du |
| collection | DOAJ |
| description | Breast cancer remains a significant global health challenge, emphasizing the pressing need for innovative therapeutic approaches. Our thorough research investigates the potential of mesoporous polydopamine nanoparticles (MPDA) as a targeted treatment for breast cancer. Meticulously crafted, these nanoparticles were loaded with honokiol (HK), which is a natural product, and then coated with functionalized hyaluronic acid (HA) to boost their ability to target breast cancer cells that overexpress CD44 receptors. The deep penetrating and photothermal (PTT) composite nanosystem combined with low-dose metformin (Met) improves the efficacy of synergetic therapy against breast tumors. The designed nanosystem exhibited exceptional biocompatibility and stability, suggesting its suitability for therapeutic use. Our in vitro studies demonstrated that the nanosystem precisely targeted and penetrated breast cancer cells, resulting in significant cell death. Additionally, in vivo studies showed that the nanosystem markedly inhibited tumor growth compared to the control group. This tumor-inhibiting effect was due to the combined action of the encapsulated HK, free Met, and the photothermal effect induced by near-infrared laser irradiation. This combination potently stimulates the expression of cleaved caspase-3 and cleaved PARP proteins, ultimately triggering cell apoptosis and effectively curbing tumor proliferation. Our research not only underscores the promising potential of nanoparticles for targeted breast cancer therapy but also sets the stage for further exploration and development of novel nanomedicine-based therapeutic strategies. |
| format | Article |
| id | doaj-art-413b052c1d3a4e5e9814e6d5c5a8cea8 |
| institution | DOAJ |
| issn | 2473-2877 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Bioengineering |
| spelling | doaj-art-413b052c1d3a4e5e9814e6d5c5a8cea82025-08-20T03:06:17ZengAIP Publishing LLCAPL Bioengineering2473-28772025-03-0191016115016115-1310.1063/5.0256571Enhanced integrated therapy for breast cancer employing Honokiol-loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low-dose metforminQianqian Du0Qianfan Zhang1Jialing Li2Xiaofei Wang3Xiangyu Gao4Guangyuan Tan5Qian Feng6Jigang Li7Yanchun Meng8Yongsheng Yu9Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, ChinaChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, ChinaDepartment of Ultrasound Diagnosis, Xiangya Hospital, Central South University, Xiangya Road, Changsha, ChinaChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, ChinaChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, ChinaChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, ChinaKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, ChinaDepartment of Laboratory, Zibo Central Hospital, Shandong, ChinaDepartment of Medical Oncology, Department of Oncology, Phase I Clinical Trial Center, Shanghai Cancer Center, Fudan University, Shanghai, ChinaChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, ChinaBreast cancer remains a significant global health challenge, emphasizing the pressing need for innovative therapeutic approaches. Our thorough research investigates the potential of mesoporous polydopamine nanoparticles (MPDA) as a targeted treatment for breast cancer. Meticulously crafted, these nanoparticles were loaded with honokiol (HK), which is a natural product, and then coated with functionalized hyaluronic acid (HA) to boost their ability to target breast cancer cells that overexpress CD44 receptors. The deep penetrating and photothermal (PTT) composite nanosystem combined with low-dose metformin (Met) improves the efficacy of synergetic therapy against breast tumors. The designed nanosystem exhibited exceptional biocompatibility and stability, suggesting its suitability for therapeutic use. Our in vitro studies demonstrated that the nanosystem precisely targeted and penetrated breast cancer cells, resulting in significant cell death. Additionally, in vivo studies showed that the nanosystem markedly inhibited tumor growth compared to the control group. This tumor-inhibiting effect was due to the combined action of the encapsulated HK, free Met, and the photothermal effect induced by near-infrared laser irradiation. This combination potently stimulates the expression of cleaved caspase-3 and cleaved PARP proteins, ultimately triggering cell apoptosis and effectively curbing tumor proliferation. Our research not only underscores the promising potential of nanoparticles for targeted breast cancer therapy but also sets the stage for further exploration and development of novel nanomedicine-based therapeutic strategies.http://dx.doi.org/10.1063/5.0256571 |
| spellingShingle | Qianqian Du Qianfan Zhang Jialing Li Xiaofei Wang Xiangyu Gao Guangyuan Tan Qian Feng Jigang Li Yanchun Meng Yongsheng Yu Enhanced integrated therapy for breast cancer employing Honokiol-loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low-dose metformin APL Bioengineering |
| title | Enhanced integrated therapy for breast cancer employing Honokiol-loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low-dose metformin |
| title_full | Enhanced integrated therapy for breast cancer employing Honokiol-loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low-dose metformin |
| title_fullStr | Enhanced integrated therapy for breast cancer employing Honokiol-loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low-dose metformin |
| title_full_unstemmed | Enhanced integrated therapy for breast cancer employing Honokiol-loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low-dose metformin |
| title_short | Enhanced integrated therapy for breast cancer employing Honokiol-loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low-dose metformin |
| title_sort | enhanced integrated therapy for breast cancer employing honokiol loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low dose metformin |
| url | http://dx.doi.org/10.1063/5.0256571 |
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