Absolute purity determination of an organic fluorine pharmaceutical voriconazole via quantitative 19F NMR and method validation

Absolute purity determination of an organic fluorine pharmaceutical voriconazole via quantitative 19F NMR and method validation

The 19F NMR spectrum has a smaller number of signals than 1H NMR, therefore, quantitative 19F NMR (19F-qNMR) can replace quantitative 1H NMR (1H-qNMR) for the absolute quantitation of organic fluorine-bearing compounds. In this study, we determined the purity of voriconazole (VCZ), an organic fluori...

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Main Authors: Nahoko Uchiyama, Junko Hosoe, Kohei Kiyota, Takanori Komatsu, Naoki Sugimoto, Kyoko Ishizuki, Tatsuo Koide, Mika Murabayashi, Taeko Shinozaki, Yoshinori Fujimine, Katsuya Ofuji, Hitoshi Shimizu, Kazuhiro Fujita, Takashi Hasebe, Yumi Asai, Eri Ena, Yoshinobu Makino, Toru Miura, Yasuhiro Muto, Katsuo Asakura, Takako Suematsu, Hitomi Abe, Ai Kohama, Takashi Goto, Masu Yasuda, Tomohiko Ueda, Yukihiro Goda
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Pharmaceutical and Biomedical Analysis Open
Subjects:
Quantitative 19F NMR
Voriconazole
Absolute purity
Organic fluorine pharmaceutical
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Online Access:http://www.sciencedirect.com/science/article/pii/S2949771X2400015X
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