Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment
Recent advances in organoid technology have revolutionized cancer biology and therapeutic interventions, offering personalized immunotherapy treatment. Organoids, three-dimensional cell cultures derived from patient tumors, accurately replicate the tumor microenvironment, providing unprecedented ins...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-09-01
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| Series: | Immuno |
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| Online Access: | https://www.mdpi.com/2673-5601/4/4/20 |
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| author | Syarifah Tiara Noorintan Chelsie Angelius Fuad Gandhi Torizal |
| author_facet | Syarifah Tiara Noorintan Chelsie Angelius Fuad Gandhi Torizal |
| author_sort | Syarifah Tiara Noorintan |
| collection | DOAJ |
| description | Recent advances in organoid technology have revolutionized cancer biology and therapeutic interventions, offering personalized immunotherapy treatment. Organoids, three-dimensional cell cultures derived from patient tumors, accurately replicate the tumor microenvironment, providing unprecedented insights into tumor-immune interactions and therapeutic responses. In this literature-based study, we discuss various culture methods for the diverse applications of organoids in cancer immunotherapy, including drug screening, personalized treatment strategies, and mechanistic studies. Additionally, we address the technological challenges associated with these methods and propose potential future solutions to accelerate the development of novel immunotherapeutic approaches. This review highlights the transformative potential of organoid models in advancing preclinical cancer immunotherapy modeling, screening, and evaluation, paving the way for more effective and personalized cancer treatments. |
| format | Article |
| id | doaj-art-413a2193179b4e35a7989ed5af157bd7 |
| institution | DOAJ |
| issn | 2673-5601 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Immuno |
| spelling | doaj-art-413a2193179b4e35a7989ed5af157bd72025-08-20T02:50:53ZengMDPI AGImmuno2673-56012024-09-014431232410.3390/immuno4040020Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized TreatmentSyarifah Tiara Noorintan0Chelsie Angelius1Fuad Gandhi Torizal2Department of Biotechnology, Faculty of Science and Technology, Universitas ‘Aisyiyah Yogyakarta, Yogyakarta 55592, IndonesiaFaculty of Medicine, Pelita Harapan University, Tangerang 15811, IndonesiaDepartment of Biotechnology, Faculty of Science and Technology, Universitas ‘Aisyiyah Yogyakarta, Yogyakarta 55592, IndonesiaRecent advances in organoid technology have revolutionized cancer biology and therapeutic interventions, offering personalized immunotherapy treatment. Organoids, three-dimensional cell cultures derived from patient tumors, accurately replicate the tumor microenvironment, providing unprecedented insights into tumor-immune interactions and therapeutic responses. In this literature-based study, we discuss various culture methods for the diverse applications of organoids in cancer immunotherapy, including drug screening, personalized treatment strategies, and mechanistic studies. Additionally, we address the technological challenges associated with these methods and propose potential future solutions to accelerate the development of novel immunotherapeutic approaches. This review highlights the transformative potential of organoid models in advancing preclinical cancer immunotherapy modeling, screening, and evaluation, paving the way for more effective and personalized cancer treatments.https://www.mdpi.com/2673-5601/4/4/20organoid modelscancer immunotherapypersonalized treatmentbioengineeringculture methods |
| spellingShingle | Syarifah Tiara Noorintan Chelsie Angelius Fuad Gandhi Torizal Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment Immuno organoid models cancer immunotherapy personalized treatment bioengineering culture methods |
| title | Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment |
| title_full | Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment |
| title_fullStr | Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment |
| title_full_unstemmed | Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment |
| title_short | Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment |
| title_sort | organoid models in cancer immunotherapy bioengineering approach for personalized treatment |
| topic | organoid models cancer immunotherapy personalized treatment bioengineering culture methods |
| url | https://www.mdpi.com/2673-5601/4/4/20 |
| work_keys_str_mv | AT syarifahtiaranoorintan organoidmodelsincancerimmunotherapybioengineeringapproachforpersonalizedtreatment AT chelsieangelius organoidmodelsincancerimmunotherapybioengineeringapproachforpersonalizedtreatment AT fuadgandhitorizal organoidmodelsincancerimmunotherapybioengineeringapproachforpersonalizedtreatment |