Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients
Despite the continuous progression in dialysis medicine, mortality and the burden of cardiovascular disease (CVD) among hemodialysis patients are still substantial. Substantial evidence suggests that proinflammatory (CD16+) monocytes contribute to the development of atherosclerosis. A cohort of 136...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/1070959 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547499564335104 |
|---|---|
| author | Yachung Jeng Paik Seong Lim Ming Ying Wu Tien-Yu Tseng Chang Hsu Chen Hung Ping Chen Tsai-Kun Wu |
| author_facet | Yachung Jeng Paik Seong Lim Ming Ying Wu Tien-Yu Tseng Chang Hsu Chen Hung Ping Chen Tsai-Kun Wu |
| author_sort | Yachung Jeng |
| collection | DOAJ |
| description | Despite the continuous progression in dialysis medicine, mortality and the burden of cardiovascular disease (CVD) among hemodialysis patients are still substantial. Substantial evidence suggests that proinflammatory (CD16+) monocytes contribute to the development of atherosclerosis. A cohort of 136 stable hemodialysis patients (follow-up: 6.25 year) was assessed to investigate the association between the proportion of CD16+ monocytes for all-cause and CVD mortalities. The CD16+ monocytes were associated with both mortalities after adjusting for a preexisting CVD history. Compared to the reference group (CD16+ monocytes within [15.6–18.6], the first and second quartile), patients with CD16+ monocytes above the highest quartile level (>21.5) had an adjusted hazard ratio (HR) of 30.85 (95% confidence interval [CI]: 7.12–133.8) for CVD mortality and 5.28 (2.07–13.49) for all-cause mortality, and those with CD16+ monocytes below the lowest quartile ≤15.6), had significantly elevated death risks after 3.5-year follow-up (HR [95% CI]: 10.9 [2.42–48.96] and 4.38 [1.45–13.24] for CV and all-cause mortalities, respectively). The hemodialysis patients with CD16+ monocyte level in a low but mostly covering normal range also portended a poor prognosis. The findings shed some light for nephrologists on future prospects of early recognizing immune dysfunction and improving early intervention outcomes. |
| format | Article |
| id | doaj-art-4135d8c2a8a444efa67942132af7ed19 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4135d8c2a8a444efa67942132af7ed192025-02-03T06:44:31ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/10709591070959Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis PatientsYachung Jeng0Paik Seong Lim1Ming Ying Wu2Tien-Yu Tseng3Chang Hsu Chen4Hung Ping Chen5Tsai-Kun Wu6Division of Biostatistics and Epidemiology, Department of Medical Research, Tungs’ Taichung MetroHarbor Hospital, Taichung, TaiwanDivision of Renal Medicine, Tungs’ Taichung MetroHarbor Hospital, Taichung, TaiwanDivision of Renal Medicine, Tungs’ Taichung MetroHarbor Hospital, Taichung, TaiwanDivision of Renal Medicine, Tungs’ Taichung MetroHarbor Hospital, Taichung, TaiwanDivision of Renal Medicine, Tungs’ Taichung MetroHarbor Hospital, Taichung, TaiwanDivision of Renal Medicine, Tungs’ Taichung MetroHarbor Hospital, Taichung, TaiwanDivision of Renal Medicine, Tungs’ Taichung MetroHarbor Hospital, Taichung, TaiwanDespite the continuous progression in dialysis medicine, mortality and the burden of cardiovascular disease (CVD) among hemodialysis patients are still substantial. Substantial evidence suggests that proinflammatory (CD16+) monocytes contribute to the development of atherosclerosis. A cohort of 136 stable hemodialysis patients (follow-up: 6.25 year) was assessed to investigate the association between the proportion of CD16+ monocytes for all-cause and CVD mortalities. The CD16+ monocytes were associated with both mortalities after adjusting for a preexisting CVD history. Compared to the reference group (CD16+ monocytes within [15.6–18.6], the first and second quartile), patients with CD16+ monocytes above the highest quartile level (>21.5) had an adjusted hazard ratio (HR) of 30.85 (95% confidence interval [CI]: 7.12–133.8) for CVD mortality and 5.28 (2.07–13.49) for all-cause mortality, and those with CD16+ monocytes below the lowest quartile ≤15.6), had significantly elevated death risks after 3.5-year follow-up (HR [95% CI]: 10.9 [2.42–48.96] and 4.38 [1.45–13.24] for CV and all-cause mortalities, respectively). The hemodialysis patients with CD16+ monocyte level in a low but mostly covering normal range also portended a poor prognosis. The findings shed some light for nephrologists on future prospects of early recognizing immune dysfunction and improving early intervention outcomes.http://dx.doi.org/10.1155/2017/1070959 |
| spellingShingle | Yachung Jeng Paik Seong Lim Ming Ying Wu Tien-Yu Tseng Chang Hsu Chen Hung Ping Chen Tsai-Kun Wu Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients Mediators of Inflammation |
| title | Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients |
| title_full | Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients |
| title_fullStr | Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients |
| title_full_unstemmed | Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients |
| title_short | Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients |
| title_sort | proportions of proinflammatory monocytes are important predictors of mortality risk in hemodialysis patients |
| url | http://dx.doi.org/10.1155/2017/1070959 |
| work_keys_str_mv | AT yachungjeng proportionsofproinflammatorymonocytesareimportantpredictorsofmortalityriskinhemodialysispatients AT paikseonglim proportionsofproinflammatorymonocytesareimportantpredictorsofmortalityriskinhemodialysispatients AT mingyingwu proportionsofproinflammatorymonocytesareimportantpredictorsofmortalityriskinhemodialysispatients AT tienyutseng proportionsofproinflammatorymonocytesareimportantpredictorsofmortalityriskinhemodialysispatients AT changhsuchen proportionsofproinflammatorymonocytesareimportantpredictorsofmortalityriskinhemodialysispatients AT hungpingchen proportionsofproinflammatorymonocytesareimportantpredictorsofmortalityriskinhemodialysispatients AT tsaikunwu proportionsofproinflammatorymonocytesareimportantpredictorsofmortalityriskinhemodialysispatients |