Tumor-Infiltrating Immune Cells and HLA Expression as Potential Biomarkers Predicting Response to PD-1 Inhibitor Therapy in Stage IV Melanoma Patients

Tumor-Infiltrating Immune Cells and HLA Expression as Potential Biomarkers Predicting Response to PD-1 Inhibitor Therapy in Stage IV Melanoma Patients

PD-1 inhibitors are known to be effective in melanoma; however, a considerable proportion of patients fail to respond to therapy, necessitating the identification of predictive markers. We examined the predictive value of tumor cell HLA class I and II expression and immune cell infiltration in melan...

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Bibliographic Details
Main Authors: Barbara Hegyi, Kristóf György Csikó, Tímea Balatoni, Georgina Fröhlich, Katalin Bőcs, Erika Tóth, Anita Mohos, Anna Rebeka Neumark, Csenge Dorottya Menyhárt, Soldano Ferrone, Andrea Ladányi
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomolecules
Subjects:
melanoma
immunotherapy
PD-1 inhibitors
biomarker
tumor-infiltrating immune cells
HLA class I and II expression
Online Access:https://www.mdpi.com/2218-273X/14/12/1609
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