Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases
Abstract Human secretory immunoglobulins (SIg) A1 and SIgA2 guide mucosal responses toward tolerance or inflammation, notably through reverse‐transcytosis, the apical‐to‐basal transport of IgA2 immune complexes via M cells of gut Peyer's patches. As such, the maintenance of a diverse gut microb...
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| Format: | Article |
| Language: | English |
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Springer Nature
2022-07-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.202115386 |
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| author | Eva Michaud Louis Waeckel Rémi Gayet Roman Goguyer‐Deschaumes Blandine Chanut Fabienne Jospin Katell Bathany Magali Monnoye Coraline Genet Amelie Prier Caroline Tokarski Philippe Gérard Xavier Roblin Nicolas Rochereau Stéphane Paul |
| author_facet | Eva Michaud Louis Waeckel Rémi Gayet Roman Goguyer‐Deschaumes Blandine Chanut Fabienne Jospin Katell Bathany Magali Monnoye Coraline Genet Amelie Prier Caroline Tokarski Philippe Gérard Xavier Roblin Nicolas Rochereau Stéphane Paul |
| author_sort | Eva Michaud |
| collection | DOAJ |
| description | Abstract Human secretory immunoglobulins (SIg) A1 and SIgA2 guide mucosal responses toward tolerance or inflammation, notably through reverse‐transcytosis, the apical‐to‐basal transport of IgA2 immune complexes via M cells of gut Peyer's patches. As such, the maintenance of a diverse gut microbiota requires broad affinity IgA and glycan–glycan interaction. Here, we asked whether IgA1 and IgA2‐microbiota interactions might be involved in dysbiosis induction during inflammatory bowel diseases. Using stool HPLC‐purified IgA, we show that reverse‐transcytosis is abrogated in ulcerative colitis (UC) while it is extended to IgA1 in Crohn's disease (CD). 16S RNA sequencing of IgA‐bound microbiota in CD and UC showed distinct IgA1‐ and IgA2‐associated microbiota; the IgA1+ fraction of CD microbiota was notably enriched in beneficial commensals. These features were associated with increased IgA anti‐glycan reactivity in CD and an opposite loss of reactivity in UC. Our results highlight previously unknown pathogenic properties of IgA in IBD that could support dysbiosis. |
| format | Article |
| id | doaj-art-412ce5dad93d49a68a3f2f1a2bf9f560 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-412ce5dad93d49a68a3f2f1a2bf9f5602025-08-20T03:46:29ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842022-07-0114812110.15252/emmm.202115386Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseasesEva Michaud0Louis Waeckel1Rémi Gayet2Roman Goguyer‐Deschaumes3Blandine Chanut4Fabienne Jospin5Katell Bathany6Magali Monnoye7Coraline Genet8Amelie Prier9Caroline Tokarski10Philippe Gérard11Xavier Roblin12Nicolas Rochereau13Stéphane Paul14CIRI – Centre International de Recherche en Infectiologie, Team GIMAP (Saint-Etienne), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308CIRI – Centre International de Recherche en Infectiologie, Team GIMAP (Saint-Etienne), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308CIRI – Centre International de Recherche en Infectiologie, Team GIMAP (Saint-Etienne), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308CIRI – Centre International de Recherche en Infectiologie, Team GIMAP (Saint-Etienne), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308CIRI – Centre International de Recherche en Infectiologie, Team GIMAP (Saint-Etienne), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308CIRI – Centre International de Recherche en Infectiologie, Team GIMAP (Saint-Etienne), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308Chimie et Biologie des Membranes et des Nano‐objets (UMR 5248), Université de Bordeaux, CNRS, Bordeaux INPMicalis Institute, INRAE, AgroParisTech, Université Paris‐SaclayInserm UMR 1098 Right, Université Bourgogne Franche‐ComtéCIRI – Centre International de Recherche en Infectiologie, Team GIMAP (Saint-Etienne), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308Chimie et Biologie des Membranes et des Nano‐objets (UMR 5248), Université de Bordeaux, CNRS, Bordeaux INPMicalis Institute, INRAE, AgroParisTech, Université Paris‐SaclayCIRI – Centre International de Recherche en Infectiologie, Team GIMAP (Saint-Etienne), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308CIRI – Centre International de Recherche en Infectiologie, Team GIMAP (Saint-Etienne), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308CIRI – Centre International de Recherche en Infectiologie, Team GIMAP (Saint-Etienne), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308Abstract Human secretory immunoglobulins (SIg) A1 and SIgA2 guide mucosal responses toward tolerance or inflammation, notably through reverse‐transcytosis, the apical‐to‐basal transport of IgA2 immune complexes via M cells of gut Peyer's patches. As such, the maintenance of a diverse gut microbiota requires broad affinity IgA and glycan–glycan interaction. Here, we asked whether IgA1 and IgA2‐microbiota interactions might be involved in dysbiosis induction during inflammatory bowel diseases. Using stool HPLC‐purified IgA, we show that reverse‐transcytosis is abrogated in ulcerative colitis (UC) while it is extended to IgA1 in Crohn's disease (CD). 16S RNA sequencing of IgA‐bound microbiota in CD and UC showed distinct IgA1‐ and IgA2‐associated microbiota; the IgA1+ fraction of CD microbiota was notably enriched in beneficial commensals. These features were associated with increased IgA anti‐glycan reactivity in CD and an opposite loss of reactivity in UC. Our results highlight previously unknown pathogenic properties of IgA in IBD that could support dysbiosis.https://doi.org/10.15252/emmm.202115386SIgAmicrobiotaglycosylationIBDimmunity |
| spellingShingle | Eva Michaud Louis Waeckel Rémi Gayet Roman Goguyer‐Deschaumes Blandine Chanut Fabienne Jospin Katell Bathany Magali Monnoye Coraline Genet Amelie Prier Caroline Tokarski Philippe Gérard Xavier Roblin Nicolas Rochereau Stéphane Paul Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases EMBO Molecular Medicine SIgA microbiota glycosylation IBD immunity |
| title | Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases |
| title_full | Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases |
| title_fullStr | Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases |
| title_full_unstemmed | Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases |
| title_short | Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases |
| title_sort | alteration of microbiota antibody mediated immune selection contributes to dysbiosis in inflammatory bowel diseases |
| topic | SIgA microbiota glycosylation IBD immunity |
| url | https://doi.org/10.15252/emmm.202115386 |
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