Gene expression profiling in pure neural leprosy: insights into pathogenesis and diagnostic biomarkers

Gene expression profiling in pure neural leprosy: insights into pathogenesis and diagnostic biomarkers

IntroductionLeprosy may affect skin and nerves, leading to permanent disabilities and deformities. Pure neural leprosy (PNL) lacks skin lesions, complicating diagnosis. Moreover there is no a specific treatment to control neural damage. Transcriptomic profiling may reveals unique gene expression cha...

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Main Authors: Mariana Martins de Athaide, Thyago Leal-Calvo, Tatiana Pereira Da Silva, Thabatta Leal Silveira Andrezo Rosa, Helen Ferreira, Bernardo Miguel de Oliveira Pascarelli, Ana Caroline Siquara de Sousa, Marcia Rodrigues Jardim, Roberta Olmo Pinheiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
pure neural leprosy
transcriptomic analysis
inflammasomes
autophagy
immunopathogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1550687/full
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