Hyperspectral imaging in living and deceased donor kidney transplantation
Abstract Objective and background Hyperspectral imaging (HSI) is an innovative, noninvasive technique that assesses tissue and organ perfusion and oxygenation. This study aimed to evaluate HSI as a predictive tool for early postoperative graft function and long-term outcomes in living donor (LD) and...
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BMC
2025-01-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-025-01576-6 |
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| author | Rasmus Wrigge Robert Sucher Fabian Haak Hans-Jonas Meyer Julia Unruh Hans-Michael Hau Matthias Mehdorn Hans-Michael Tautenhahn Daniel Seehofer Uwe Scheuermann |
| author_facet | Rasmus Wrigge Robert Sucher Fabian Haak Hans-Jonas Meyer Julia Unruh Hans-Michael Hau Matthias Mehdorn Hans-Michael Tautenhahn Daniel Seehofer Uwe Scheuermann |
| author_sort | Rasmus Wrigge |
| collection | DOAJ |
| description | Abstract Objective and background Hyperspectral imaging (HSI) is an innovative, noninvasive technique that assesses tissue and organ perfusion and oxygenation. This study aimed to evaluate HSI as a predictive tool for early postoperative graft function and long-term outcomes in living donor (LD) and deceased donor (DD) kidney transplantation (KT). Patients and methods HSI of kidney allograft parenchyma from 19 LD and 51 DD kidneys was obtained intraoperatively 15 minutes after reperfusion. Using the dedicated HSI TIVITA Tissue System, indices of tissue oxygenation (StO2), perfusion (near-infrared [NIR]), organ hemoglobin (OHI), and tissue water (TWI) were calculated and then analyzed retrospectively. Results LD kidneys had superior intraoperative HSI values of StO2 (0.78 ± 0.13 versus 0.63 ± 0.24; P = 0.001) and NIR (0.67 ± 0.10 versus 0.56 ± 0.27; P = 0.016) compared to DD kidneys. Delayed graft function (DGF) was observed in 18 cases (26%), in which intraoperative HSI showed significantly lower values of StO2 (0.78 ± 0.07 versus 0.35 ± 0.21; P < 0.001) and NIR (0.67 ± 0.11 versus 0.34 ± 0.32; P < 0.001). Receiver operating characteristic curve analysis demonstrated an excellent predictive value of HSI for the development of DGF, with an area under the curve of 0.967 for StO2 and 0.801 for NIR. Kidney grafts with low StO2 values (cut-off point 0.6) showed reduced renal function with a low glomerular filtration rate and elevated urea levels in the first two weeks after KT. Three years after KT, graft survival was also inferior in the group with initially low StO2 values. Conclusion HSI is a useful tool for predicting DGF in living and deceased KT and may assist in estimating short-term allograft function. However, further studies with expanded cohorts are needed to evaluate the association between HSI and long-term graft outcomes. |
| format | Article |
| id | doaj-art-412474f8f0244de6b1a103ce4a7c63de |
| institution | Kabale University |
| issn | 1471-2342 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Medical Imaging |
| spelling | doaj-art-412474f8f0244de6b1a103ce4a7c63de2025-02-02T12:47:51ZengBMCBMC Medical Imaging1471-23422025-01-0125111110.1186/s12880-025-01576-6Hyperspectral imaging in living and deceased donor kidney transplantationRasmus Wrigge0Robert Sucher1Fabian Haak2Hans-Jonas Meyer3Julia Unruh4Hans-Michael Hau5Matthias Mehdorn6Hans-Michael Tautenhahn7Daniel Seehofer8Uwe Scheuermann9Department of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of LeipzigDepartment of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of LeipzigDepartment of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of LeipzigDepartment of Diagnostic and Interventional Radiology, University Hospital of LeipzigDepartment of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of LeipzigDepartment of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of LeipzigDepartment of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of LeipzigDepartment of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of LeipzigDepartment of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of LeipzigDepartment of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of LeipzigAbstract Objective and background Hyperspectral imaging (HSI) is an innovative, noninvasive technique that assesses tissue and organ perfusion and oxygenation. This study aimed to evaluate HSI as a predictive tool for early postoperative graft function and long-term outcomes in living donor (LD) and deceased donor (DD) kidney transplantation (KT). Patients and methods HSI of kidney allograft parenchyma from 19 LD and 51 DD kidneys was obtained intraoperatively 15 minutes after reperfusion. Using the dedicated HSI TIVITA Tissue System, indices of tissue oxygenation (StO2), perfusion (near-infrared [NIR]), organ hemoglobin (OHI), and tissue water (TWI) were calculated and then analyzed retrospectively. Results LD kidneys had superior intraoperative HSI values of StO2 (0.78 ± 0.13 versus 0.63 ± 0.24; P = 0.001) and NIR (0.67 ± 0.10 versus 0.56 ± 0.27; P = 0.016) compared to DD kidneys. Delayed graft function (DGF) was observed in 18 cases (26%), in which intraoperative HSI showed significantly lower values of StO2 (0.78 ± 0.07 versus 0.35 ± 0.21; P < 0.001) and NIR (0.67 ± 0.11 versus 0.34 ± 0.32; P < 0.001). Receiver operating characteristic curve analysis demonstrated an excellent predictive value of HSI for the development of DGF, with an area under the curve of 0.967 for StO2 and 0.801 for NIR. Kidney grafts with low StO2 values (cut-off point 0.6) showed reduced renal function with a low glomerular filtration rate and elevated urea levels in the first two weeks after KT. Three years after KT, graft survival was also inferior in the group with initially low StO2 values. Conclusion HSI is a useful tool for predicting DGF in living and deceased KT and may assist in estimating short-term allograft function. However, further studies with expanded cohorts are needed to evaluate the association between HSI and long-term graft outcomes.https://doi.org/10.1186/s12880-025-01576-6Hyperspectral imagingLiving donorDeceased donorKidney transplantationDelayed graft functionOutcome |
| spellingShingle | Rasmus Wrigge Robert Sucher Fabian Haak Hans-Jonas Meyer Julia Unruh Hans-Michael Hau Matthias Mehdorn Hans-Michael Tautenhahn Daniel Seehofer Uwe Scheuermann Hyperspectral imaging in living and deceased donor kidney transplantation BMC Medical Imaging Hyperspectral imaging Living donor Deceased donor Kidney transplantation Delayed graft function Outcome |
| title | Hyperspectral imaging in living and deceased donor kidney transplantation |
| title_full | Hyperspectral imaging in living and deceased donor kidney transplantation |
| title_fullStr | Hyperspectral imaging in living and deceased donor kidney transplantation |
| title_full_unstemmed | Hyperspectral imaging in living and deceased donor kidney transplantation |
| title_short | Hyperspectral imaging in living and deceased donor kidney transplantation |
| title_sort | hyperspectral imaging in living and deceased donor kidney transplantation |
| topic | Hyperspectral imaging Living donor Deceased donor Kidney transplantation Delayed graft function Outcome |
| url | https://doi.org/10.1186/s12880-025-01576-6 |
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