Defying the Odds: A Case of Successfully Treated Harlequin Ichthyosis in Lebanon
ABSTRACT Harlequin ichthyosis is a rare skin disorder affecting newborns characterized by a scaly skin, flexed limbs, ectropium, and eclabium. The overall incidence of HI is 1 in 300,000 births, with approximately only 200 cases reported worldwide. Some studies uncovered a TH17 immune skewing in pat...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.70111 |
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| author | Bassel Hamam Sarah Saleh Miled Yaacoub Houssein Chebbo Sarah Jalloul Karam Karam Rima Houmani |
| author_facet | Bassel Hamam Sarah Saleh Miled Yaacoub Houssein Chebbo Sarah Jalloul Karam Karam Rima Houmani |
| author_sort | Bassel Hamam |
| collection | DOAJ |
| description | ABSTRACT Harlequin ichthyosis is a rare skin disorder affecting newborns characterized by a scaly skin, flexed limbs, ectropium, and eclabium. The overall incidence of HI is 1 in 300,000 births, with approximately only 200 cases reported worldwide. Some studies uncovered a TH17 immune skewing in patients with HI, which is also seen in psoriasis. We herein present a case of a newborn found to have harlequin ichthyosis, whom his mother is known to have psoriasis. The baby was treated with topical antibiotics and retinoid creams. The baby then exhibited smoother skin with less scaling and flatter fissures. |
| format | Article |
| id | doaj-art-41233382ed614325b49c3a396c9d4b37 |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-41233382ed614325b49c3a396c9d4b372025-01-24T05:08:47ZengWileyClinical Case Reports2050-09042025-01-01131n/an/a10.1002/ccr3.70111Defying the Odds: A Case of Successfully Treated Harlequin Ichthyosis in LebanonBassel Hamam0Sarah Saleh1Miled Yaacoub2Houssein Chebbo3Sarah Jalloul4Karam Karam5Rima Houmani6Department of Radiology University of Balamand Balamand LebanonFaculty of Medicine University of Balamand Balamand LebanonFaculty of Medicine University of Balamand Balamand LebanonFaculty of Medicine University of Balamand Balamand LebanonDepartment of Gastroenterology, Faculty of Medicine University of Balamand Balamand LebanonDepartment of Gastroenterology, Faculty of Medicine University of Balamand Balamand LebanonDepartment of Obstetrics and Gynecology Lebanese University Beirut LebanonABSTRACT Harlequin ichthyosis is a rare skin disorder affecting newborns characterized by a scaly skin, flexed limbs, ectropium, and eclabium. The overall incidence of HI is 1 in 300,000 births, with approximately only 200 cases reported worldwide. Some studies uncovered a TH17 immune skewing in patients with HI, which is also seen in psoriasis. We herein present a case of a newborn found to have harlequin ichthyosis, whom his mother is known to have psoriasis. The baby was treated with topical antibiotics and retinoid creams. The baby then exhibited smoother skin with less scaling and flatter fissures.https://doi.org/10.1002/ccr3.70111case reportharlequin ichthyosishyperkeratotic scalesretinoid creamstopical antibiotics |
| spellingShingle | Bassel Hamam Sarah Saleh Miled Yaacoub Houssein Chebbo Sarah Jalloul Karam Karam Rima Houmani Defying the Odds: A Case of Successfully Treated Harlequin Ichthyosis in Lebanon Clinical Case Reports case report harlequin ichthyosis hyperkeratotic scales retinoid creams topical antibiotics |
| title | Defying the Odds: A Case of Successfully Treated Harlequin Ichthyosis in Lebanon |
| title_full | Defying the Odds: A Case of Successfully Treated Harlequin Ichthyosis in Lebanon |
| title_fullStr | Defying the Odds: A Case of Successfully Treated Harlequin Ichthyosis in Lebanon |
| title_full_unstemmed | Defying the Odds: A Case of Successfully Treated Harlequin Ichthyosis in Lebanon |
| title_short | Defying the Odds: A Case of Successfully Treated Harlequin Ichthyosis in Lebanon |
| title_sort | defying the odds a case of successfully treated harlequin ichthyosis in lebanon |
| topic | case report harlequin ichthyosis hyperkeratotic scales retinoid creams topical antibiotics |
| url | https://doi.org/10.1002/ccr3.70111 |
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