Anti-Retroviral Treatment in dr. Sardjito Central General Hospital Yogyakarta
Background: Adverse cutaneous drug reactions (ACDRs) affect 2-3% of hospitalized patients globally, wherein approximately 2% (1 in 1,000 cases) accounted for a severe form of cutaneous drug reactions. Out of all dermatologic diagnoses recorded by HIV patients, eight-point twenty-five percent of pati...
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| Format: | Article |
| Language: | Indonesian |
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Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga
2024-11-01
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| Series: | Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) |
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| Online Access: | https://e-journal.unair.ac.id/BIKK/article/view/56993 |
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| author | Labitta Pachira Aquaira Sri Awalia Febriana Nurwestu Rusetiyanti |
| author_facet | Labitta Pachira Aquaira Sri Awalia Febriana Nurwestu Rusetiyanti |
| author_sort | Labitta Pachira Aquaira |
| collection | DOAJ |
| description | Background: Adverse cutaneous drug reactions (ACDRs) affect 2-3% of hospitalized patients globally, wherein approximately 2% (1 in 1,000 cases) accounted for a severe form of cutaneous drug reactions. Out of all dermatologic diagnoses recorded by HIV patients, eight-point twenty-five percent of patients feature ACDRs, indicating that these patients are 100 times more inclined to develop unfortunate, severe reactions to anti-retroviral treatment. Therefore, there is an urgency in identifying the prevalence of ACDRs in HIV patients taking anti-retroviral treatment. Purpose: The aim of this study is to calculate the prevalence of anti-retroviral drug-induced ACDRs in HIV-positive patients in Central General Hospital, in the time period of January 2015 to December 2017. Methods: This study analyzed inpatient and outpatient medical records from January 2015 to December 2017 in the Dermatology and Venereology Department of dr. Sardjito Central General Hospital, which recorded ART-induced ACDRs manifestations. Result: This study revealed a prevalence of 0.095% of ACDRs as a result of ART administration, with 1.5% HIV-positive patients affected by ACDRs in response to ART medication. A m sex ratio of 2:1 with an average age of 30.4 ± 5.94 years old was found. The most predominant type of ACDR found in HIV-positive patients receiving ART was maculopapular rash (46.7%), while the most common type of drug within the ART regimen to cause such ACDR was Nevirapine (25.8%). Discussion: Nevirapine was the most common type of causative drug, for monotherapy (22.6%) and polytherapy (25.8%). |
| format | Article |
| id | doaj-art-411fef930cf84cbcb78bf60e2f1fdf47 |
| institution | OA Journals |
| issn | 1978-4279 2549-4082 |
| language | Indonesian |
| publishDate | 2024-11-01 |
| publisher | Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga |
| record_format | Article |
| series | Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) |
| spelling | doaj-art-411fef930cf84cbcb78bf60e2f1fdf472025-08-20T02:36:02ZindDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas AirlanggaBerkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology)1978-42792549-40822024-11-0136316216710.20473/bikk.V36.3.2024.162-16755158Anti-Retroviral Treatment in dr. Sardjito Central General Hospital YogyakartaLabitta Pachira Aquaira0Sri Awalia Febriana1https://orcid.org/0000-0002-8209-2820Nurwestu Rusetiyanti2https://orcid.org/0009-0008-1950-7764Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, IndonesiaDepartment of Dermatology and Venereology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, IndonesiaDepartment of Dermatology and Venereology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, IndonesiaBackground: Adverse cutaneous drug reactions (ACDRs) affect 2-3% of hospitalized patients globally, wherein approximately 2% (1 in 1,000 cases) accounted for a severe form of cutaneous drug reactions. Out of all dermatologic diagnoses recorded by HIV patients, eight-point twenty-five percent of patients feature ACDRs, indicating that these patients are 100 times more inclined to develop unfortunate, severe reactions to anti-retroviral treatment. Therefore, there is an urgency in identifying the prevalence of ACDRs in HIV patients taking anti-retroviral treatment. Purpose: The aim of this study is to calculate the prevalence of anti-retroviral drug-induced ACDRs in HIV-positive patients in Central General Hospital, in the time period of January 2015 to December 2017. Methods: This study analyzed inpatient and outpatient medical records from January 2015 to December 2017 in the Dermatology and Venereology Department of dr. Sardjito Central General Hospital, which recorded ART-induced ACDRs manifestations. Result: This study revealed a prevalence of 0.095% of ACDRs as a result of ART administration, with 1.5% HIV-positive patients affected by ACDRs in response to ART medication. A m sex ratio of 2:1 with an average age of 30.4 ± 5.94 years old was found. The most predominant type of ACDR found in HIV-positive patients receiving ART was maculopapular rash (46.7%), while the most common type of drug within the ART regimen to cause such ACDR was Nevirapine (25.8%). Discussion: Nevirapine was the most common type of causative drug, for monotherapy (22.6%) and polytherapy (25.8%).https://e-journal.unair.ac.id/BIKK/article/view/56993adverse cutaneous drug reactionsart regimennevirapinemaculopapular rashhiv-positive patients |
| spellingShingle | Labitta Pachira Aquaira Sri Awalia Febriana Nurwestu Rusetiyanti Anti-Retroviral Treatment in dr. Sardjito Central General Hospital Yogyakarta Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) adverse cutaneous drug reactions art regimen nevirapine maculopapular rash hiv-positive patients |
| title | Anti-Retroviral Treatment in dr. Sardjito Central General Hospital Yogyakarta |
| title_full | Anti-Retroviral Treatment in dr. Sardjito Central General Hospital Yogyakarta |
| title_fullStr | Anti-Retroviral Treatment in dr. Sardjito Central General Hospital Yogyakarta |
| title_full_unstemmed | Anti-Retroviral Treatment in dr. Sardjito Central General Hospital Yogyakarta |
| title_short | Anti-Retroviral Treatment in dr. Sardjito Central General Hospital Yogyakarta |
| title_sort | anti retroviral treatment in dr sardjito central general hospital yogyakarta |
| topic | adverse cutaneous drug reactions art regimen nevirapine maculopapular rash hiv-positive patients |
| url | https://e-journal.unair.ac.id/BIKK/article/view/56993 |
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