Innovative Strategies in Oncology: Bacterial Membrane Vesicle-Based Drug Delivery Systems for Cancer Diagnosis and Therapy
Outer membrane vesicles (OMVs) are double-layered structures of nanoscale lipids released by gram-negative bacteria. They have the same membrane composition and characteristics as primitive cells, which enables them to penetrate cells and tissues efficiently. These OMVs exhibit excellent membrane st...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/1/58 |
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| author | Guodong Li Shuangpeng Pu Lisiyao You Yuan Gao Yuexia Zhong Huadong Zhao Dong Fan Xiyan Lu |
| author_facet | Guodong Li Shuangpeng Pu Lisiyao You Yuan Gao Yuexia Zhong Huadong Zhao Dong Fan Xiyan Lu |
| author_sort | Guodong Li |
| collection | DOAJ |
| description | Outer membrane vesicles (OMVs) are double-layered structures of nanoscale lipids released by gram-negative bacteria. They have the same membrane composition and characteristics as primitive cells, which enables them to penetrate cells and tissues efficiently. These OMVs exhibit excellent membrane stability, immunogenicity, safety, and permeability (which makes it easier for them to penetrate into tumour tissue), making them suitable for developing cancer vaccines and drug delivery systems. Recent studies have focused on engineering OMVs to enhance tumour-targeting capabilities, reduce toxicity, and extend circulation time in vivo. This article reviews the latest progress in OMV engineering for tumour treatment and discusses the challenges associated with the use of OMV-based antitumour therapy in clinical practice. |
| format | Article |
| id | doaj-art-411f6955e4634503b03d3f3187812eae |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-411f6955e4634503b03d3f3187812eae2025-01-24T13:45:45ZengMDPI AGPharmaceutics1999-49232025-01-011715810.3390/pharmaceutics17010058Innovative Strategies in Oncology: Bacterial Membrane Vesicle-Based Drug Delivery Systems for Cancer Diagnosis and TherapyGuodong Li0Shuangpeng Pu1Lisiyao You2Yuan Gao3Yuexia Zhong4Huadong Zhao5Dong Fan6Xiyan Lu7College of Life Sciences, Northwest University, Xi’an 710069, ChinaCollege of Life Sciences, Northwest University, Xi’an 710069, ChinaCollege of Life Sciences, Northwest University, Xi’an 710069, ChinaState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi’an 710032, ChinaOutpatient Department of the Second Affiliated Hospital of the Fourth Military Medical University, Xi’an 710032, ChinaDepartment of General Surgery, Tangdu Hospital, Air Force Medical University, Xi’an 710038, ChinaDepartment of General Surgery, Tangdu Hospital, Air Force Medical University, Xi’an 710038, ChinaOutpatient Department of the Second Affiliated Hospital of the Fourth Military Medical University, Xi’an 710032, ChinaOuter membrane vesicles (OMVs) are double-layered structures of nanoscale lipids released by gram-negative bacteria. They have the same membrane composition and characteristics as primitive cells, which enables them to penetrate cells and tissues efficiently. These OMVs exhibit excellent membrane stability, immunogenicity, safety, and permeability (which makes it easier for them to penetrate into tumour tissue), making them suitable for developing cancer vaccines and drug delivery systems. Recent studies have focused on engineering OMVs to enhance tumour-targeting capabilities, reduce toxicity, and extend circulation time in vivo. This article reviews the latest progress in OMV engineering for tumour treatment and discusses the challenges associated with the use of OMV-based antitumour therapy in clinical practice.https://www.mdpi.com/1999-4923/17/1/58OMVcancer diagnosiscancer therapydrug delivery system |
| spellingShingle | Guodong Li Shuangpeng Pu Lisiyao You Yuan Gao Yuexia Zhong Huadong Zhao Dong Fan Xiyan Lu Innovative Strategies in Oncology: Bacterial Membrane Vesicle-Based Drug Delivery Systems for Cancer Diagnosis and Therapy Pharmaceutics OMV cancer diagnosis cancer therapy drug delivery system |
| title | Innovative Strategies in Oncology: Bacterial Membrane Vesicle-Based Drug Delivery Systems for Cancer Diagnosis and Therapy |
| title_full | Innovative Strategies in Oncology: Bacterial Membrane Vesicle-Based Drug Delivery Systems for Cancer Diagnosis and Therapy |
| title_fullStr | Innovative Strategies in Oncology: Bacterial Membrane Vesicle-Based Drug Delivery Systems for Cancer Diagnosis and Therapy |
| title_full_unstemmed | Innovative Strategies in Oncology: Bacterial Membrane Vesicle-Based Drug Delivery Systems for Cancer Diagnosis and Therapy |
| title_short | Innovative Strategies in Oncology: Bacterial Membrane Vesicle-Based Drug Delivery Systems for Cancer Diagnosis and Therapy |
| title_sort | innovative strategies in oncology bacterial membrane vesicle based drug delivery systems for cancer diagnosis and therapy |
| topic | OMV cancer diagnosis cancer therapy drug delivery system |
| url | https://www.mdpi.com/1999-4923/17/1/58 |
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