Advances in DNA methylation in screening for Lung cancer
Lung cancer (LC) represents the most life-threatening malignancy in the world today. Currently, low-dose chest computed tomography (LDCT) and tumor markers represent the mainstay for LC screening. However, these screening methods can only detect LC that already formed. Thus there is a need for the d...
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| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2025-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/25/bioconf_icbb2025_01024.pdf |
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| Summary: | Lung cancer (LC) represents the most life-threatening malignancy in the world today. Currently, low-dose chest computed tomography (LDCT) and tumor markers represent the mainstay for LC screening. However, these screening methods can only detect LC that already formed. Thus there is a need for the development of new tests for LC screening. A substantial body of evidence from scientific research indicates that dysregulated DNA methylation may play a role in the pathogenesis of a variety of diseases, including cancer. Consequently, DNA methylation testing is anticipated to become a screening test for LC. This paper examines the high-throughput detection of DNA methylation in a range of biological specimens, including tissues, blood, and others, which contributed to its potential as a marker for LC screening, recurrence monitoring, and prognosis. Numerous combinations of markers can be constructed to predict LC incidence and prognosis based on the detection of DNA methylation. |
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| ISSN: | 2117-4458 |