Prognostic Significance of Inflammatory and Nutritional Indices for Serous Ovary Cancer
Background: Cancer prognoses have been indicated to be associated with Onodera’s prognostic nutritional index (OPNI), the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune-inflammatory index (SII). We investigated the prognostic value of the OPNI,...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2024-08-01
|
| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/51/8/10.31083/j.ceog5108183 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849305035043766272 |
|---|---|
| author | Yan Han Weiqin Lv Jianfei Guo Yun Shang Fan Yang Xiaomin Zhang Keyuan Xiao Liang Zong Wenqing Hu |
| author_facet | Yan Han Weiqin Lv Jianfei Guo Yun Shang Fan Yang Xiaomin Zhang Keyuan Xiao Liang Zong Wenqing Hu |
| author_sort | Yan Han |
| collection | DOAJ |
| description | Background: Cancer prognoses have been indicated to be associated with Onodera’s prognostic nutritional index (OPNI), the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune-inflammatory index (SII). We investigated the prognostic value of the OPNI, NLR, PLR, and SII for serous ovary cancer (SOC). Methods: We retrospectively analyzed the cases of 133 patients with SOC treated at our institution from 2014 to 2021. The survival of the patients was assessed utilizing the Kaplan-Meier method to analyze overall survival (OS). Additionally, a multivariate analysis employing the Cox proportional hazard regression model was conducted to identify the independent prognostic factors for SOC. The positive event for the ROC diagnosis is mortality during follow-up. Results: The results revealed the following optimal cut-off points: OPNI, 45.5; NLR, 2.3; PLR, 224.4; and SII, 747.5. A comparative analysis demonstrated significant differences between high- and low-OPNI score groups in the treatment method, tumor stage, lymph node metastasis, albumin, NLR, PLR, and SII; other indicators are not irrelevant. We also observed that the OPNI, NLR, PLR, and SII were related to OS: the OPNI score was positively correlated with OS whereas the NLR, PLR, and SII values were negatively correlated with OS. These results identified the OPNI as the best prognostic indicator for SOC. Conclusions: Our findings demonstrate that the OPNI, NLR, PLR, and SII could be used as predictive and prognostic parameters for SOC. |
| format | Article |
| id | doaj-art-411c0d97aea54cc4bf21b30ee087abae |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-411c0d97aea54cc4bf21b30ee087abae2025-08-20T03:55:35ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-08-0151818310.31083/j.ceog5108183S0390-6663(24)02343-1Prognostic Significance of Inflammatory and Nutritional Indices for Serous Ovary CancerYan Han0Weiqin Lv1Jianfei Guo2Yun Shang3Fan Yang4Xiaomin Zhang5Keyuan Xiao6Liang Zong7Wenqing Hu8Department of Gynecology, Changzhi People's Hospital, The Third Clinical College of Changzhi Medical College, 046000 Changzhi, Shanxi, ChinaDepartment of Gynecology, Yuncheng Central Hospital, The Affiliated Hospital of Shanxi Medical University, 044000 Yuncheng, Shanxi, ChinaDepartment of Gynecology, Changzhi People's Hospital, The Third Clinical College of Changzhi Medical College, 046000 Changzhi, Shanxi, ChinaDepartment of Gynecology, Yuncheng Central Hospital, The Affiliated Hospital of Shanxi Medical University, 044000 Yuncheng, Shanxi, ChinaDepartment of Central laboratory, Changzhi People's Hospital, The Third Clinical College of Changzhi Medical College, 046000 Changzhi, Shanxi, ChinaDepartment of Central laboratory, Changzhi People's Hospital, The Third Clinical College of Changzhi Medical College, 046000 Changzhi, Shanxi, ChinaDepartment of Central laboratory, Changzhi People's Hospital, The Third Clinical College of Changzhi Medical College, 046000 Changzhi, Shanxi, ChinaDepartment of Central laboratory, Changzhi People's Hospital, The Third Clinical College of Changzhi Medical College, 046000 Changzhi, Shanxi, ChinaDepartment of Gastrointestinal Surgery, Changzhi People's Hospital, The Third Clinical College of Changzhi Medical College, 046000 Changzhi, Shanxi, ChinaBackground: Cancer prognoses have been indicated to be associated with Onodera’s prognostic nutritional index (OPNI), the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune-inflammatory index (SII). We investigated the prognostic value of the OPNI, NLR, PLR, and SII for serous ovary cancer (SOC). Methods: We retrospectively analyzed the cases of 133 patients with SOC treated at our institution from 2014 to 2021. The survival of the patients was assessed utilizing the Kaplan-Meier method to analyze overall survival (OS). Additionally, a multivariate analysis employing the Cox proportional hazard regression model was conducted to identify the independent prognostic factors for SOC. The positive event for the ROC diagnosis is mortality during follow-up. Results: The results revealed the following optimal cut-off points: OPNI, 45.5; NLR, 2.3; PLR, 224.4; and SII, 747.5. A comparative analysis demonstrated significant differences between high- and low-OPNI score groups in the treatment method, tumor stage, lymph node metastasis, albumin, NLR, PLR, and SII; other indicators are not irrelevant. We also observed that the OPNI, NLR, PLR, and SII were related to OS: the OPNI score was positively correlated with OS whereas the NLR, PLR, and SII values were negatively correlated with OS. These results identified the OPNI as the best prognostic indicator for SOC. Conclusions: Our findings demonstrate that the OPNI, NLR, PLR, and SII could be used as predictive and prognostic parameters for SOC.https://www.imrpress.com/journal/CEOG/51/8/10.31083/j.ceog5108183serous ovary cancerneutrophil to lymphocyte ratioplatelet to lymphocyte ratiosystemic immune-inflammatory indexonodera's prognostic nutritional index |
| spellingShingle | Yan Han Weiqin Lv Jianfei Guo Yun Shang Fan Yang Xiaomin Zhang Keyuan Xiao Liang Zong Wenqing Hu Prognostic Significance of Inflammatory and Nutritional Indices for Serous Ovary Cancer Clinical and Experimental Obstetrics & Gynecology serous ovary cancer neutrophil to lymphocyte ratio platelet to lymphocyte ratio systemic immune-inflammatory index onodera's prognostic nutritional index |
| title | Prognostic Significance of Inflammatory and Nutritional Indices for Serous Ovary Cancer |
| title_full | Prognostic Significance of Inflammatory and Nutritional Indices for Serous Ovary Cancer |
| title_fullStr | Prognostic Significance of Inflammatory and Nutritional Indices for Serous Ovary Cancer |
| title_full_unstemmed | Prognostic Significance of Inflammatory and Nutritional Indices for Serous Ovary Cancer |
| title_short | Prognostic Significance of Inflammatory and Nutritional Indices for Serous Ovary Cancer |
| title_sort | prognostic significance of inflammatory and nutritional indices for serous ovary cancer |
| topic | serous ovary cancer neutrophil to lymphocyte ratio platelet to lymphocyte ratio systemic immune-inflammatory index onodera's prognostic nutritional index |
| url | https://www.imrpress.com/journal/CEOG/51/8/10.31083/j.ceog5108183 |
| work_keys_str_mv | AT yanhan prognosticsignificanceofinflammatoryandnutritionalindicesforserousovarycancer AT weiqinlv prognosticsignificanceofinflammatoryandnutritionalindicesforserousovarycancer AT jianfeiguo prognosticsignificanceofinflammatoryandnutritionalindicesforserousovarycancer AT yunshang prognosticsignificanceofinflammatoryandnutritionalindicesforserousovarycancer AT fanyang prognosticsignificanceofinflammatoryandnutritionalindicesforserousovarycancer AT xiaominzhang prognosticsignificanceofinflammatoryandnutritionalindicesforserousovarycancer AT keyuanxiao prognosticsignificanceofinflammatoryandnutritionalindicesforserousovarycancer AT liangzong prognosticsignificanceofinflammatoryandnutritionalindicesforserousovarycancer AT wenqinghu prognosticsignificanceofinflammatoryandnutritionalindicesforserousovarycancer |