Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary Brachytherapy
Purpose. In this study, we evaluated our experience with salvage brachytherapy after discovery of biochemical recurrence after a prior brachytherapy procedure. Methods and Materials. From 2001 through 2012 twenty-one patients treated by brachytherapy within University of Kentucky or from outside cen...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2016/9561494 |
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| author | John M. Lacy William A. Wilson Raevti Bole Li Chen Ali S. Meigooni Randall G. Rowland William H. St. Clair |
| author_facet | John M. Lacy William A. Wilson Raevti Bole Li Chen Ali S. Meigooni Randall G. Rowland William H. St. Clair |
| author_sort | John M. Lacy |
| collection | DOAJ |
| description | Purpose. In this study, we evaluated our experience with salvage brachytherapy after discovery of biochemical recurrence after a prior brachytherapy procedure. Methods and Materials. From 2001 through 2012 twenty-one patients treated by brachytherapy within University of Kentucky or from outside centers developed biochemical failure and had no evidence of metastases. Computed tomography (CT) scans were evaluated; patients who had an underseeded portion of their prostate were considered for reimplantation. Results. The majority of the patients in this study (61.9%) were low risk and median presalvage PSA was 3.49 (range 17.41–1.68). Mean follow-up was 61 months. At last follow-up after reseeding, 11/21 (52.4%) were free of biochemical recurrence. There was a trend towards decreased freedom from biochemical recurrence in low risk patients (p=0.12). International Prostate Symptom Scores (IPSS) increased at 3-month follow-up visits but decreased and were equivalent to baseline scores at 18 months. Conclusions. Salvage brachytherapy after primary brachytherapy is possible; however, in our experience the side-effect profile after the second brachytherapy procedure was higher than after the first brachytherapy procedure. In this cohort of patients we demonstrate that approximately 50% oncologic control, low risk patients appear to have better outcomes than others. |
| format | Article |
| id | doaj-art-4117ca72c4aa4cd19eec3685f1770f63 |
| institution | OA Journals |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-4117ca72c4aa4cd19eec3685f1770f632025-08-20T02:07:52ZengWileyProstate Cancer2090-31112090-312X2016-01-01201610.1155/2016/95614949561494Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary BrachytherapyJohn M. Lacy0William A. Wilson1Raevti Bole2Li Chen3Ali S. Meigooni4Randall G. Rowland5William H. St. Clair6Department of Urology, University of Kentucky College of Medicine, Lexington, KY 40536, USADepartment of Radiation Oncology, University of Kentucky College of Medicine, Lexington, KY 40536, USAUniversity of Kentucky College of Medicine, Lexington, KY 40536, USADepartment of Biostatistics, University of Kentucky College of Public Health, Lexington, KY 40536, USAComprehensive Cancer Centers of Nevada, Las Vegas, NV 89169, USADepartment of Urology, University of Kentucky College of Medicine, Lexington, KY 40536, USADepartment of Radiation Oncology, University of Kentucky College of Medicine, Lexington, KY 40536, USAPurpose. In this study, we evaluated our experience with salvage brachytherapy after discovery of biochemical recurrence after a prior brachytherapy procedure. Methods and Materials. From 2001 through 2012 twenty-one patients treated by brachytherapy within University of Kentucky or from outside centers developed biochemical failure and had no evidence of metastases. Computed tomography (CT) scans were evaluated; patients who had an underseeded portion of their prostate were considered for reimplantation. Results. The majority of the patients in this study (61.9%) were low risk and median presalvage PSA was 3.49 (range 17.41–1.68). Mean follow-up was 61 months. At last follow-up after reseeding, 11/21 (52.4%) were free of biochemical recurrence. There was a trend towards decreased freedom from biochemical recurrence in low risk patients (p=0.12). International Prostate Symptom Scores (IPSS) increased at 3-month follow-up visits but decreased and were equivalent to baseline scores at 18 months. Conclusions. Salvage brachytherapy after primary brachytherapy is possible; however, in our experience the side-effect profile after the second brachytherapy procedure was higher than after the first brachytherapy procedure. In this cohort of patients we demonstrate that approximately 50% oncologic control, low risk patients appear to have better outcomes than others.http://dx.doi.org/10.1155/2016/9561494 |
| spellingShingle | John M. Lacy William A. Wilson Raevti Bole Li Chen Ali S. Meigooni Randall G. Rowland William H. St. Clair Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary Brachytherapy Prostate Cancer |
| title | Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary Brachytherapy |
| title_full | Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary Brachytherapy |
| title_fullStr | Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary Brachytherapy |
| title_full_unstemmed | Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary Brachytherapy |
| title_short | Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary Brachytherapy |
| title_sort | salvage brachytherapy for biochemically recurrent prostate cancer following primary brachytherapy |
| url | http://dx.doi.org/10.1155/2016/9561494 |
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