Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting

Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting

Abstract Physiological adaptations to fasting enable humans to survive for prolonged periods without food and involve molecular pathways that may drive life-prolonging effects of dietary restriction in model organisms. Mobilization of fatty acids and glycerol from adipocyte lipid stores by canonical...

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Main Authors: GV Naveen Kumar, Rui-Sheng Wang, Ankit X. Sharma, Natalie L. David, Tânia Amorim, Daniel S. Sinden, Nandini K. Doshi, Martin Wabitsch, Sebastien Gingras, Asim Ejaz, J. Peter Rubin, Bradley A. Maron, Pouneh K. Fazeli, Matthew L. Steinhauser
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56613-3
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