Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

Abstract Bone metastasis is the second most common site of distant metastatic spread in renal cell carcinoma (RCC) patients, significantly contributing to cancer‐related mortality. The metastatic process is driven by both intrinsic tumor cell properties, such as cancer stem cell‐like characteristics...

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Main Authors: Jianye Zhang, Qi Zhang, Gang Lin, Ying Wang, Juan Li, Ping Wang, Jie Qi, Yuan Liang, Shiming He, Yanqing Gong, Ninghan Feng, Yang Wang, Yuanyuan Ma, Mei Zhang, Yue Shi, Xuesong Li, Weimin Ci, Liqun Zhou
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
APM
bone metastasis
microenvironment
renal cancer
treatment
Online Access:https://doi.org/10.1002/advs.202501011
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