Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases
The blood–brain barrier (BBB) is a critical structure that maintains brain homeostasis by selectively regulating nutrient influx and waste efflux. Not surprisingly, it is often compromised in neurodegenerative diseases. In addition to its involvement in these pathologies, the BBB also represents a s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/3/281 |
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| author | Adriana Jiménez Enrique Estudillo Mara A. Guzmán-Ruiz Nieves Herrera-Mundo Georgina Victoria-Acosta Enoc Mariano Cortés-Malagón Adolfo López-Ornelas |
| author_facet | Adriana Jiménez Enrique Estudillo Mara A. Guzmán-Ruiz Nieves Herrera-Mundo Georgina Victoria-Acosta Enoc Mariano Cortés-Malagón Adolfo López-Ornelas |
| author_sort | Adriana Jiménez |
| collection | DOAJ |
| description | The blood–brain barrier (BBB) is a critical structure that maintains brain homeostasis by selectively regulating nutrient influx and waste efflux. Not surprisingly, it is often compromised in neurodegenerative diseases. In addition to its involvement in these pathologies, the BBB also represents a significant challenge for drug delivery into the central nervous system. Nanoparticles (NPs) have been widely explored as drug carriers capable of overcoming this barrier and effectively transporting therapies to the brain. However, their potential to directly address and ameliorate BBB dysfunction has received limited attention. In this review, we examine how NPs enhance drug delivery across the BBB to treat neurodegenerative diseases and explore emerging strategies to restore the integrity of this vital structure. |
| format | Article |
| id | doaj-art-410bda06339e4508a75bd1d2c013d126 |
| institution | OA Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-410bda06339e4508a75bd1d2c013d1262025-08-20T01:48:53ZengMDPI AGPharmaceutics1999-49232025-02-0117328110.3390/pharmaceutics17030281Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative DiseasesAdriana Jiménez0Enrique Estudillo1Mara A. Guzmán-Ruiz2Nieves Herrera-Mundo3Georgina Victoria-Acosta4Enoc Mariano Cortés-Malagón5Adolfo López-Ornelas6División de Investigación, Hospital Juárez de México, Ciudad de México 07760, MexicoLaboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México 14269, MexicoDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoDepartamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoDivisión de Investigación, Hospital Juárez de México, Ciudad de México 07760, MexicoDivisión de Investigación, Hospital Juárez de México, Ciudad de México 07760, MexicoDivisión de Investigación, Hospital Juárez de México, Ciudad de México 07760, MexicoThe blood–brain barrier (BBB) is a critical structure that maintains brain homeostasis by selectively regulating nutrient influx and waste efflux. Not surprisingly, it is often compromised in neurodegenerative diseases. In addition to its involvement in these pathologies, the BBB also represents a significant challenge for drug delivery into the central nervous system. Nanoparticles (NPs) have been widely explored as drug carriers capable of overcoming this barrier and effectively transporting therapies to the brain. However, their potential to directly address and ameliorate BBB dysfunction has received limited attention. In this review, we examine how NPs enhance drug delivery across the BBB to treat neurodegenerative diseases and explore emerging strategies to restore the integrity of this vital structure.https://www.mdpi.com/1999-4923/17/3/281nanotechnologynanoparticlesneurodegenerative diseasesblood–brain barrierstem cells |
| spellingShingle | Adriana Jiménez Enrique Estudillo Mara A. Guzmán-Ruiz Nieves Herrera-Mundo Georgina Victoria-Acosta Enoc Mariano Cortés-Malagón Adolfo López-Ornelas Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases Pharmaceutics nanotechnology nanoparticles neurodegenerative diseases blood–brain barrier stem cells |
| title | Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases |
| title_full | Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases |
| title_fullStr | Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases |
| title_full_unstemmed | Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases |
| title_short | Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases |
| title_sort | nanotechnology to overcome blood brain barrier permeability and damage in neurodegenerative diseases |
| topic | nanotechnology nanoparticles neurodegenerative diseases blood–brain barrier stem cells |
| url | https://www.mdpi.com/1999-4923/17/3/281 |
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