Faecalibacterium prausnitzii: A Next-Generation Probiotic in Gut Disease Improvement
The researchers are paying more attention to the role of gut commensal bacteria in health development beyond the classical pathogens. It has been widely demonstrated that dysbiosis, which means the alternations of the gut microbial structure, is closely associated with development of intestinal chro...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2021/6666114 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568422295142400 |
|---|---|
| author | Xiaoya He Shuyang Zhao Yan Li |
| author_facet | Xiaoya He Shuyang Zhao Yan Li |
| author_sort | Xiaoya He |
| collection | DOAJ |
| description | The researchers are paying more attention to the role of gut commensal bacteria in health development beyond the classical pathogens. It has been widely demonstrated that dysbiosis, which means the alternations of the gut microbial structure, is closely associated with development of intestinal chronic inflammation-related diseases such as inflammatory bowel disease (IBD), and even infectious diseases including bacterial and viral infection. Thus, for reshaping ecological balance, a growing body of the literatures have proposed numerous strategies to modulate the structure of the gut microbiota, which provide more revelation for amelioration of these inflammation or infection-related diseases. While the ameliorative effects of traditional probiotics seem negligeable, emerging next generation probiotics (NGPs) start to receive great attention as new preventive and therapeutic tools. Encouragingly, within the last decade, the intestinal symbiotic bacterium Faecalibacterium prausnitzii has emerged as the “sentinel of the gut,” with multifunction of anti-inflammation, gut barrier enhancement, and butyrate production. A lower abundance of F. prausnitzii has been shown in IBD, Clostridium difficile infection (CDI), and virus infection such as COVID-19. It is reported that intervention with higher richness of F. prausnitzii through dietary modulation, fecal microbiota transplantation, or culture strategy can protect the mice or the subjects from inflammatory diseases. Therefore, F. prausnitzii may have potential ability to reduce microbial translocation and inflammation, preventing occurrences of gastrointestinal comorbidities especially in COVID-19 patients. |
| format | Article |
| id | doaj-art-410baaede51e41afa5d8fcfbb3b43920 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-410baaede51e41afa5d8fcfbb3b439202025-02-03T00:59:01ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932021-01-01202110.1155/2021/66661146666114Faecalibacterium prausnitzii: A Next-Generation Probiotic in Gut Disease ImprovementXiaoya He0Shuyang Zhao1Yan Li2State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu 610041, ChinaQueen Mary School of Medical College, Jiangxi Medical College, Qianhu Campus, Nanchang University, No. 1290 Xuefu Street, Jiangxi 330031, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu 610041, ChinaThe researchers are paying more attention to the role of gut commensal bacteria in health development beyond the classical pathogens. It has been widely demonstrated that dysbiosis, which means the alternations of the gut microbial structure, is closely associated with development of intestinal chronic inflammation-related diseases such as inflammatory bowel disease (IBD), and even infectious diseases including bacterial and viral infection. Thus, for reshaping ecological balance, a growing body of the literatures have proposed numerous strategies to modulate the structure of the gut microbiota, which provide more revelation for amelioration of these inflammation or infection-related diseases. While the ameliorative effects of traditional probiotics seem negligeable, emerging next generation probiotics (NGPs) start to receive great attention as new preventive and therapeutic tools. Encouragingly, within the last decade, the intestinal symbiotic bacterium Faecalibacterium prausnitzii has emerged as the “sentinel of the gut,” with multifunction of anti-inflammation, gut barrier enhancement, and butyrate production. A lower abundance of F. prausnitzii has been shown in IBD, Clostridium difficile infection (CDI), and virus infection such as COVID-19. It is reported that intervention with higher richness of F. prausnitzii through dietary modulation, fecal microbiota transplantation, or culture strategy can protect the mice or the subjects from inflammatory diseases. Therefore, F. prausnitzii may have potential ability to reduce microbial translocation and inflammation, preventing occurrences of gastrointestinal comorbidities especially in COVID-19 patients.http://dx.doi.org/10.1155/2021/6666114 |
| spellingShingle | Xiaoya He Shuyang Zhao Yan Li Faecalibacterium prausnitzii: A Next-Generation Probiotic in Gut Disease Improvement Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Faecalibacterium prausnitzii: A Next-Generation Probiotic in Gut Disease Improvement |
| title_full | Faecalibacterium prausnitzii: A Next-Generation Probiotic in Gut Disease Improvement |
| title_fullStr | Faecalibacterium prausnitzii: A Next-Generation Probiotic in Gut Disease Improvement |
| title_full_unstemmed | Faecalibacterium prausnitzii: A Next-Generation Probiotic in Gut Disease Improvement |
| title_short | Faecalibacterium prausnitzii: A Next-Generation Probiotic in Gut Disease Improvement |
| title_sort | faecalibacterium prausnitzii a next generation probiotic in gut disease improvement |
| url | http://dx.doi.org/10.1155/2021/6666114 |
| work_keys_str_mv | AT xiaoyahe faecalibacteriumprausnitziianextgenerationprobioticingutdiseaseimprovement AT shuyangzhao faecalibacteriumprausnitziianextgenerationprobioticingutdiseaseimprovement AT yanli faecalibacteriumprausnitziianextgenerationprobioticingutdiseaseimprovement |