Cell-Specific Aptamers as Emerging Therapeutics
Aptamers are short nucleic acids that bind to defined targets with high affinity and specificity. The first aptamers have been selected about two decades ago by an in vitro process named SELEX (systematic evolution of ligands by exponential...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2011/904750 |
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| _version_ | 1832559202256551936 |
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| author | Cindy Meyer Ulrich Hahn Andrea Rentmeister |
| author_facet | Cindy Meyer Ulrich Hahn Andrea Rentmeister |
| author_sort | Cindy Meyer |
| collection | DOAJ |
| description | Aptamers are short nucleic
acids that bind to defined targets with high affinity
and specificity. The first aptamers have been selected
about two decades ago by an in vitro process named
SELEX (systematic evolution of ligands by exponential
enrichment). Since then, numerous aptamers with
specificities for a variety of targets from small
molecules to proteins or even whole cells have been
selected. Their applications range from biosensing and
diagnostics to therapy and target-oriented drug
delivery. More recently, selections using complex
targets such as live cells have become feasible. This
paper summarizes progress in cell-SELEX techniques
and highlights recent developments, particularly in
the field of medically relevant aptamers with a focus
on therapeutic and drug-delivery
applications. |
| format | Article |
| id | doaj-art-41071506a153478da8edf266c1b80969 |
| institution | Kabale University |
| issn | 2090-021X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-41071506a153478da8edf266c1b809692025-02-03T01:30:32ZengWileyJournal of Nucleic Acids2090-021X2011-01-01201110.4061/2011/904750904750Cell-Specific Aptamers as Emerging TherapeuticsCindy Meyer0Ulrich Hahn1Andrea Rentmeister2Chemistry Department, MIN Faculty, Institute for Biochemistry and Molecular Biology, Hamburg University, Martin-Luther-King-Platz 6, 20146 Hamburg, GermanyChemistry Department, MIN Faculty, Institute for Biochemistry and Molecular Biology, Hamburg University, Martin-Luther-King-Platz 6, 20146 Hamburg, GermanyChemistry Department, MIN Faculty, Institute for Biochemistry and Molecular Biology, Hamburg University, Martin-Luther-King-Platz 6, 20146 Hamburg, GermanyAptamers are short nucleic acids that bind to defined targets with high affinity and specificity. The first aptamers have been selected about two decades ago by an in vitro process named SELEX (systematic evolution of ligands by exponential enrichment). Since then, numerous aptamers with specificities for a variety of targets from small molecules to proteins or even whole cells have been selected. Their applications range from biosensing and diagnostics to therapy and target-oriented drug delivery. More recently, selections using complex targets such as live cells have become feasible. This paper summarizes progress in cell-SELEX techniques and highlights recent developments, particularly in the field of medically relevant aptamers with a focus on therapeutic and drug-delivery applications.http://dx.doi.org/10.4061/2011/904750 |
| spellingShingle | Cindy Meyer Ulrich Hahn Andrea Rentmeister Cell-Specific Aptamers as Emerging Therapeutics Journal of Nucleic Acids |
| title | Cell-Specific Aptamers as Emerging Therapeutics |
| title_full | Cell-Specific Aptamers as Emerging Therapeutics |
| title_fullStr | Cell-Specific Aptamers as Emerging Therapeutics |
| title_full_unstemmed | Cell-Specific Aptamers as Emerging Therapeutics |
| title_short | Cell-Specific Aptamers as Emerging Therapeutics |
| title_sort | cell specific aptamers as emerging therapeutics |
| url | http://dx.doi.org/10.4061/2011/904750 |
| work_keys_str_mv | AT cindymeyer cellspecificaptamersasemergingtherapeutics AT ulrichhahn cellspecificaptamersasemergingtherapeutics AT andrearentmeister cellspecificaptamersasemergingtherapeutics |