High intensity focused ultrasound periosteal ablation in an animal model: potential for palliation of bone metastases
Purpose Radiotherapy is standard-of-care for painful bone metastases yet has limitations and associated side effects. Ablation of sensory nerves endings along the periosteum with magnetic resonance imaging guided high intensity focused ultrasound (MRgFUS) proved safe and clinically effective for pai...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2025.2543330 |
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| author | Ron Aginsky Suzanne Leblang Eric Miller Brian Skoglind Abraham Nyska Niv Rebhun Michael Gofeld Jean-Francois Aubry Arik Hananel |
| author_facet | Ron Aginsky Suzanne Leblang Eric Miller Brian Skoglind Abraham Nyska Niv Rebhun Michael Gofeld Jean-Francois Aubry Arik Hananel |
| author_sort | Ron Aginsky |
| collection | DOAJ |
| description | Purpose Radiotherapy is standard-of-care for painful bone metastases yet has limitations and associated side effects. Ablation of sensory nerves endings along the periosteum with magnetic resonance imaging guided high intensity focused ultrasound (MRgFUS) proved safe and clinically effective for pain relief in patients with bone metastases, received FDA and CE approval, but has not gained widespread adoption due to significant cost and procedural and logistical complexity. This preclinical study evaluated the safety and feasibility of a fluoroscopy-guided high intensity focused ultrasound platform to ablate a targeted region along the surface of bones.Methods Two healthy adult pigs received 6 kJ to 10 kJ sonications to the femur, ileum, and ribs. Animals were followed-up for 3 months. Longitudinal clinical observation and follow up magnetic resonance imaging (MRI), and computed tomography (CT) scans were performed. After sacrifice, the targeted bone and adjacent tissues were sent for histopathological evaluation to confirm thermal ablation.Results Clinical observations revealed no neurological or musculoskeletal deficits. MRI scans on day 5 demonstrated robust ablation in all targeted sites. At 12 weeks, CT scans and histopathological evaluation showed complete healing of ablated regions.Conclusions Periosteal bone ablation using the Neurolyser XR in a healthy porcine model is feasible with no adverse events, and no radiological or histological evidence of lasting injury or fracture to the targeted bones. |
| format | Article |
| id | doaj-art-40faa4dc9f7d4f0f921959bfb3a8eb13 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-40faa4dc9f7d4f0f921959bfb3a8eb132025-08-20T03:38:54ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572025-12-0142110.1080/02656736.2025.2543330High intensity focused ultrasound periosteal ablation in an animal model: potential for palliation of bone metastasesRon Aginsky0Suzanne Leblang1Eric Miller2Brian Skoglind3Abraham Nyska4Niv Rebhun5Michael Gofeld6Jean-Francois Aubry7Arik Hananel8FUSMobile, Alpharetta, GA, USAFocused Ultrasound Foundation, Charlottesville, VA, USAFUSMobile, Alpharetta, GA, USAFUSMobile, Alpharetta, GA, USAConsultant in Toxicologic Pathology, Tel Aviv University, Tel Aviv, IsraelFUSMobile, Alpharetta, GA, USAUnika Medical Centre, North York, CanadaPhysics for Medicine Paris, Inserm, ESPCI Paris, CNRS, PSI, Research University, Paris, FranceFUSMobile, Alpharetta, GA, USAPurpose Radiotherapy is standard-of-care for painful bone metastases yet has limitations and associated side effects. Ablation of sensory nerves endings along the periosteum with magnetic resonance imaging guided high intensity focused ultrasound (MRgFUS) proved safe and clinically effective for pain relief in patients with bone metastases, received FDA and CE approval, but has not gained widespread adoption due to significant cost and procedural and logistical complexity. This preclinical study evaluated the safety and feasibility of a fluoroscopy-guided high intensity focused ultrasound platform to ablate a targeted region along the surface of bones.Methods Two healthy adult pigs received 6 kJ to 10 kJ sonications to the femur, ileum, and ribs. Animals were followed-up for 3 months. Longitudinal clinical observation and follow up magnetic resonance imaging (MRI), and computed tomography (CT) scans were performed. After sacrifice, the targeted bone and adjacent tissues were sent for histopathological evaluation to confirm thermal ablation.Results Clinical observations revealed no neurological or musculoskeletal deficits. MRI scans on day 5 demonstrated robust ablation in all targeted sites. At 12 weeks, CT scans and histopathological evaluation showed complete healing of ablated regions.Conclusions Periosteal bone ablation using the Neurolyser XR in a healthy porcine model is feasible with no adverse events, and no radiological or histological evidence of lasting injury or fracture to the targeted bones.https://www.tandfonline.com/doi/10.1080/02656736.2025.2543330Thermal ablationhigh intensity focused ultrasoundporcine modelbone ablationperiosteum |
| spellingShingle | Ron Aginsky Suzanne Leblang Eric Miller Brian Skoglind Abraham Nyska Niv Rebhun Michael Gofeld Jean-Francois Aubry Arik Hananel High intensity focused ultrasound periosteal ablation in an animal model: potential for palliation of bone metastases International Journal of Hyperthermia Thermal ablation high intensity focused ultrasound porcine model bone ablation periosteum |
| title | High intensity focused ultrasound periosteal ablation in an animal model: potential for palliation of bone metastases |
| title_full | High intensity focused ultrasound periosteal ablation in an animal model: potential for palliation of bone metastases |
| title_fullStr | High intensity focused ultrasound periosteal ablation in an animal model: potential for palliation of bone metastases |
| title_full_unstemmed | High intensity focused ultrasound periosteal ablation in an animal model: potential for palliation of bone metastases |
| title_short | High intensity focused ultrasound periosteal ablation in an animal model: potential for palliation of bone metastases |
| title_sort | high intensity focused ultrasound periosteal ablation in an animal model potential for palliation of bone metastases |
| topic | Thermal ablation high intensity focused ultrasound porcine model bone ablation periosteum |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2025.2543330 |
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