Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway
We investigated the effect of Dalbergioidin (DAL), a well-known natural product extracted from Uraria crinita, on doxorubicin- (DXR-) induced renal fibrosis in mice. The mice were pretreated for 7 days with DAL followed by a single injection of DXR (10 mg/kg) via the tail vein. Renal function was an...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/5147571 |
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| author | Xianguo Ren Yun Bo Junting Fan Maosheng Chen Daliang Xu Yang Dong Haowei He Xianzhi Ren Rong Qu Yulian Jin Weihong Zhao Changliang Xu |
| author_facet | Xianguo Ren Yun Bo Junting Fan Maosheng Chen Daliang Xu Yang Dong Haowei He Xianzhi Ren Rong Qu Yulian Jin Weihong Zhao Changliang Xu |
| author_sort | Xianguo Ren |
| collection | DOAJ |
| description | We investigated the effect of Dalbergioidin (DAL), a well-known natural product extracted from Uraria crinita, on doxorubicin- (DXR-) induced renal fibrosis in mice. The mice were pretreated for 7 days with DAL followed by a single injection of DXR (10 mg/kg) via the tail vein. Renal function was analyzed 5 weeks after DXR treatment. DXR caused nephrotoxicity. The symptoms of nephrotic syndrome were greatly improved after DAL treatment. The indices of renal fibrosis, the phosphorylation of Smad3, and the expression of alpha-smooth muscle actin (α-SMA), fibronectin, collagen III (Col III), E-cadherin, TGF-β, and Smad7 in response to DXR were all similarly modified by DAL. The present findings suggest that DAL improved the markers for kidney damage investigated in this model of DXR-induced experimental nephrotoxicity. |
| format | Article |
| id | doaj-art-40f9228c210f4fc08a42a64f0505f989 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-40f9228c210f4fc08a42a64f0505f9892025-08-20T03:55:35ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/51475715147571Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal PathwayXianguo Ren0Yun Bo1Junting Fan2Maosheng Chen3Daliang Xu4Yang Dong5Haowei He6Xianzhi Ren7Rong Qu8Yulian Jin9Weihong Zhao10Changliang Xu11National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, ChinaDepartment of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaSchool of Pharmacy, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Zhejiang Provincial People’s Hospital, Hangzhou, ChinaDepartment of Nephrology, Anhui Provincial Children’s Hospital, Hefei, ChinaDepartment of Nephrology, Anhui Provincial Children’s Hospital, Hefei, ChinaDepartment of Urology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, ChinaNanjing University of Traditional Chinese Medicine, Nanjing, ChinaDepartment of Nephrology, Anhui Provincial Children’s Hospital, Hefei, ChinaDepartment of Nephrology, Anhui Provincial Children’s Hospital, Hefei, ChinaDepartment of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaNational Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, ChinaWe investigated the effect of Dalbergioidin (DAL), a well-known natural product extracted from Uraria crinita, on doxorubicin- (DXR-) induced renal fibrosis in mice. The mice were pretreated for 7 days with DAL followed by a single injection of DXR (10 mg/kg) via the tail vein. Renal function was analyzed 5 weeks after DXR treatment. DXR caused nephrotoxicity. The symptoms of nephrotic syndrome were greatly improved after DAL treatment. The indices of renal fibrosis, the phosphorylation of Smad3, and the expression of alpha-smooth muscle actin (α-SMA), fibronectin, collagen III (Col III), E-cadherin, TGF-β, and Smad7 in response to DXR were all similarly modified by DAL. The present findings suggest that DAL improved the markers for kidney damage investigated in this model of DXR-induced experimental nephrotoxicity.http://dx.doi.org/10.1155/2016/5147571 |
| spellingShingle | Xianguo Ren Yun Bo Junting Fan Maosheng Chen Daliang Xu Yang Dong Haowei He Xianzhi Ren Rong Qu Yulian Jin Weihong Zhao Changliang Xu Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway Mediators of Inflammation |
| title | Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway |
| title_full | Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway |
| title_fullStr | Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway |
| title_full_unstemmed | Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway |
| title_short | Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway |
| title_sort | dalbergioidin ameliorates doxorubicin induced renal fibrosis by suppressing the tgf β signal pathway |
| url | http://dx.doi.org/10.1155/2016/5147571 |
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