Repeated-dose toxicity and immunogenicity evaluation of a recombinant subunit COVID-19 vaccine (ZF2001) in rats

Repeated-dose toxicity and immunogenicity evaluation of a recombinant subunit COVID-19 vaccine (ZF2001) in rats

Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had given rise to a massive epidemic. Owing to the high morbidity and mortality of COVID-19 and the lack of effective therapies, safe and effective vaccination is the optimum choice for control...

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Bibliographic Details
Main Authors: Ruimin Sun, Lijuan Xia, Guangbiao She, Jinrong Li, Yiru Wang, Yunxiang Chen, Qian Yang, Siming Zhang, Fang Liu, Ying Chen, Liyan Zhang, Chengda Zhang, Wanqiang Lv, Enqi Huang, Lijiang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
COVID-19
subunit protein vaccine
ZF2001
repeated-dose toxicity study
immune response
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1548787/full
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