Three-dimensional traction technology and its application in mechanomedicine
Endogenous forces generated by living cells are essential for biological processes and physiological functions of cells and tissues. Over the last several decades, numerous methods for detecting traction forces have been developed. Here we review these methods and discuss their respective strengths...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Mechanobiology in Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949907025000191 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850192577607761920 |
|---|---|
| author | Xinman Chen Chenyang Ji Xi Liu Ning Wang Fuxiang Wei Junwei Chen |
| author_facet | Xinman Chen Chenyang Ji Xi Liu Ning Wang Fuxiang Wei Junwei Chen |
| author_sort | Xinman Chen |
| collection | DOAJ |
| description | Endogenous forces generated by living cells are essential for biological processes and physiological functions of cells and tissues. Over the last several decades, numerous methods for detecting traction forces have been developed. Here we review these methods and discuss their respective strengths and limitations. Being able to reliably quantify tractions in living cells and tissues are critical in understanding how forces drive and regulate cell and tissue functions in physiology and diseases. |
| format | Article |
| id | doaj-art-40f5155e05f84b6dbd52e9b34f5a7a72 |
| institution | OA Journals |
| issn | 2949-9070 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Mechanobiology in Medicine |
| spelling | doaj-art-40f5155e05f84b6dbd52e9b34f5a7a722025-08-20T02:14:30ZengElsevierMechanobiology in Medicine2949-90702025-09-013310013110.1016/j.mbm.2025.100131Three-dimensional traction technology and its application in mechanomedicineXinman Chen0Chenyang Ji1Xi Liu2Ning Wang3Fuxiang Wei4Junwei Chen5Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074 ChinaKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074 ChinaKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074 ChinaThe Institute for Mechanobiology, Northeastern University, Boston, MA 02115, USA; Department of Bioengineering, College of Engineering, Northeastern University, Boston, MA 02115, USA; Corresponding author. The Institute for Mechanobiology, Northeastern University, Boston, MA 02115, USA.Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074 China; Corresponding author.Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074 China; Corresponding author.Endogenous forces generated by living cells are essential for biological processes and physiological functions of cells and tissues. Over the last several decades, numerous methods for detecting traction forces have been developed. Here we review these methods and discuss their respective strengths and limitations. Being able to reliably quantify tractions in living cells and tissues are critical in understanding how forces drive and regulate cell and tissue functions in physiology and diseases.http://www.sciencedirect.com/science/article/pii/S29499070250001913D traction forceTraction force microscopyTumor microenvironmentMechanomedicine |
| spellingShingle | Xinman Chen Chenyang Ji Xi Liu Ning Wang Fuxiang Wei Junwei Chen Three-dimensional traction technology and its application in mechanomedicine Mechanobiology in Medicine 3D traction force Traction force microscopy Tumor microenvironment Mechanomedicine |
| title | Three-dimensional traction technology and its application in mechanomedicine |
| title_full | Three-dimensional traction technology and its application in mechanomedicine |
| title_fullStr | Three-dimensional traction technology and its application in mechanomedicine |
| title_full_unstemmed | Three-dimensional traction technology and its application in mechanomedicine |
| title_short | Three-dimensional traction technology and its application in mechanomedicine |
| title_sort | three dimensional traction technology and its application in mechanomedicine |
| topic | 3D traction force Traction force microscopy Tumor microenvironment Mechanomedicine |
| url | http://www.sciencedirect.com/science/article/pii/S2949907025000191 |
| work_keys_str_mv | AT xinmanchen threedimensionaltractiontechnologyanditsapplicationinmechanomedicine AT chenyangji threedimensionaltractiontechnologyanditsapplicationinmechanomedicine AT xiliu threedimensionaltractiontechnologyanditsapplicationinmechanomedicine AT ningwang threedimensionaltractiontechnologyanditsapplicationinmechanomedicine AT fuxiangwei threedimensionaltractiontechnologyanditsapplicationinmechanomedicine AT junweichen threedimensionaltractiontechnologyanditsapplicationinmechanomedicine |