Mini review of plant products as food supplement against MSG-induced liver injury: antioxidant, oxidative stress and histological prospects
Monosodium glutamate (MSG) is an odorless white solid crystalline derived from the amino acid glutamic acid. It is widely used as a flavor enhancer, but its excessive consumption has been associated with toxicity to various organs. In MSG-induced liver injury, few mechanisms have been identified, wh...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1522814/full |
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| author | Dwi Pratiwi Kasmara Erlina Abdullah Zaliha Harun Fatmi Nirmala Sari Norhashima Abd Rashid Seong Lin Teoh |
| author_facet | Dwi Pratiwi Kasmara Erlina Abdullah Zaliha Harun Fatmi Nirmala Sari Norhashima Abd Rashid Seong Lin Teoh |
| author_sort | Dwi Pratiwi Kasmara |
| collection | DOAJ |
| description | Monosodium glutamate (MSG) is an odorless white solid crystalline derived from the amino acid glutamic acid. It is widely used as a flavor enhancer, but its excessive consumption has been associated with toxicity to various organs. In MSG-induced liver injury, few mechanisms have been identified, which started with the generation of reactive oxygen species that leads to oxidative stress which further causes liver injury. In response to this health concern, there is growing interest in various plant products such as plant extracts, flavonoids and phenolic compounds that were able to minimize oxidative stress, serum transaminases and scavenge free radicals in the liver after MSG administration. This review explores the potential of various plant products as dietary supplements to MSG-induced liver injury, focusing on their antioxidant activities, modulatory effects on liver function markers, and histological outcomes. By compiling this evidence, this review provides insights into their potential as preventive strategies against MSG-related liver toxicity, supporting their inclusion in dietary regimens for the maintenance of liver function. |
| format | Article |
| id | doaj-art-40f0e28d43cd4052a19a1e10d753aa63 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-40f0e28d43cd4052a19a1e10d753aa632025-01-24T05:21:17ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011610.3389/fphar.2025.15228141522814Mini review of plant products as food supplement against MSG-induced liver injury: antioxidant, oxidative stress and histological prospectsDwi Pratiwi Kasmara0Erlina Abdullah1Zaliha Harun2Fatmi Nirmala Sari3Norhashima Abd Rashid4Seong Lin Teoh5Department of Biomedical Science, School of Nursing and Applied Science, Lincoln University College, Petaling Jaya, Selangor, MalaysiaDepartment of Biotechnology, School of Nursing and Applied Science, Lincoln University College, Petaling Jaya, Selangor, MalaysiaDepartment of Nutrition, School of Nursing and Applied Science, Lincoln University College, Petaling Jaya, Selangor, MalaysiaDepartment of Biomedical Science, School of Nursing and Applied Science, Lincoln University College, Petaling Jaya, Selangor, MalaysiaDepartment of Biomedical Science, School of Nursing and Applied Science, Lincoln University College, Petaling Jaya, Selangor, MalaysiaDepartment of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaMonosodium glutamate (MSG) is an odorless white solid crystalline derived from the amino acid glutamic acid. It is widely used as a flavor enhancer, but its excessive consumption has been associated with toxicity to various organs. In MSG-induced liver injury, few mechanisms have been identified, which started with the generation of reactive oxygen species that leads to oxidative stress which further causes liver injury. In response to this health concern, there is growing interest in various plant products such as plant extracts, flavonoids and phenolic compounds that were able to minimize oxidative stress, serum transaminases and scavenge free radicals in the liver after MSG administration. This review explores the potential of various plant products as dietary supplements to MSG-induced liver injury, focusing on their antioxidant activities, modulatory effects on liver function markers, and histological outcomes. By compiling this evidence, this review provides insights into their potential as preventive strategies against MSG-related liver toxicity, supporting their inclusion in dietary regimens for the maintenance of liver function.https://www.frontiersin.org/articles/10.3389/fphar.2025.1522814/fullmonosodium glutamateliver injuryoxidative stressherbal medicineplant productscomplementary medicine |
| spellingShingle | Dwi Pratiwi Kasmara Erlina Abdullah Zaliha Harun Fatmi Nirmala Sari Norhashima Abd Rashid Seong Lin Teoh Mini review of plant products as food supplement against MSG-induced liver injury: antioxidant, oxidative stress and histological prospects Frontiers in Pharmacology monosodium glutamate liver injury oxidative stress herbal medicine plant products complementary medicine |
| title | Mini review of plant products as food supplement against MSG-induced liver injury: antioxidant, oxidative stress and histological prospects |
| title_full | Mini review of plant products as food supplement against MSG-induced liver injury: antioxidant, oxidative stress and histological prospects |
| title_fullStr | Mini review of plant products as food supplement against MSG-induced liver injury: antioxidant, oxidative stress and histological prospects |
| title_full_unstemmed | Mini review of plant products as food supplement against MSG-induced liver injury: antioxidant, oxidative stress and histological prospects |
| title_short | Mini review of plant products as food supplement against MSG-induced liver injury: antioxidant, oxidative stress and histological prospects |
| title_sort | mini review of plant products as food supplement against msg induced liver injury antioxidant oxidative stress and histological prospects |
| topic | monosodium glutamate liver injury oxidative stress herbal medicine plant products complementary medicine |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1522814/full |
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