Dose of Incorporated Immunodominant Antigen in Recombinant BCG Impacts Modestly on Th1 Immune Response and Protective Efficiency against Mycobacterium tuberculosis in Mice

Dose of Incorporated Immunodominant Antigen in Recombinant BCG Impacts Modestly on Th1 Immune Response and Protective Efficiency against Mycobacterium tuberculosis in Mice

One approach for improving BCG efficacy is to utilize BCG as vehicle to develop recombinant BCG (rBCG) strains overexpressing Mycobacterium tuberculosis (M. tb) antigens. Also expression level of a candidate antigen should impact the final T cell responses conferred by rBCG. In this study, based on...

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Bibliographic Details
Main Authors:	Hui Ma, Kang Wu, Fang Liu, Hua Yang, Han Kang, Ning-Ning Chen, Qin Yuan, Wen-Jiang Zhou, Xiao-Yong Fan
Format:	Article
Language:	English
Published:	Wiley 2014-01-01
Series:	Journal of Immunology Research
Online Access:	http://dx.doi.org/10.1155/2014/196124
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