Nutritional Value of Palm Meristem from Phoenix dactylifera L. and Its Effect on Polycystic Ovary Syndrome in Female Rats Induced with Estradiol Valerate
Objective: Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age. The objective of our investigation is to study the protective effect of hydroethanolic extract of palm meristem (HEPM) on female rats with PCOS. Materials and Methods: The experimental...
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| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | World Journal of Traditional Chinese Medicine |
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| Online Access: | https://journals.lww.com/10.4103/wjtcm.wjtcm_65_24 |
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| author | Ghofran Hadi Mashkour Sangar Naser Mirazi Nasim Hayati Roodbari Abdolkarim Hossieni |
| author_facet | Ghofran Hadi Mashkour Sangar Naser Mirazi Nasim Hayati Roodbari Abdolkarim Hossieni |
| author_sort | Ghofran Hadi Mashkour Sangar |
| collection | DOAJ |
| description | Objective:
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age. The objective of our investigation is to study the protective effect of hydroethanolic extract of palm meristem (HEPM) on female rats with PCOS.
Materials and Methods:
The experimental study involved the placement of 42 adult female Wistar rats (n = 7) into six groups, with the control group receiving 0.25 ml of physiological serum by gavage daily, the sham group getting 0.25 ml of olive oil, and the HEPM 250, 500, and 500 per se group taking HEPM by gavage daily. PCOS was induced with estradiol valerate (EV), which was administered through a subcutaneous injection at 2 mg/kg volume using 0.25 ml of olive oil. After experiments, all animals were subjected to anesthesia, and serums were extracted for biochemical and hormonal evaluation.
Results:
EV showed marked increases in serum levels of testosterone and luteinizing hormone when compared with the control group. Significantly, the EV group decreased 17-β estradiol, progesterone, and follicle-stimulating hormone. There was a significant alteration in hormonal levels across the treatment groups. The serum malondialdehyde levels and total oxidant status were elevated in the EV group. In addition, the serum levels of total antioxidant capacity, glutathione, and glutathione peroxidase were significantly lower in the EV group than in control rats. In the treatment groups, HEPM significantly reverses the oxidant/antioxidant balance and ameliorates the adverse effect of PCOS on oxidative stress.
Conclusion:
The study findings indicated that the HEPM effectively safeguarded ovarian tissue from developing PCOS in the presence of EV. |
| format | Article |
| id | doaj-art-40e9449c0f604993bd729ddda15b3a86 |
| institution | Kabale University |
| issn | 2311-8571 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | World Journal of Traditional Chinese Medicine |
| spelling | doaj-art-40e9449c0f604993bd729ddda15b3a862025-01-16T08:46:39ZengWolters Kluwer Medknow PublicationsWorld Journal of Traditional Chinese Medicine2311-85712024-12-0110447648410.4103/wjtcm.wjtcm_65_24Nutritional Value of Palm Meristem from Phoenix dactylifera L. and Its Effect on Polycystic Ovary Syndrome in Female Rats Induced with Estradiol ValerateGhofran Hadi Mashkour SangarNaser MiraziNasim Hayati RoodbariAbdolkarim HossieniObjective: Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age. The objective of our investigation is to study the protective effect of hydroethanolic extract of palm meristem (HEPM) on female rats with PCOS. Materials and Methods: The experimental study involved the placement of 42 adult female Wistar rats (n = 7) into six groups, with the control group receiving 0.25 ml of physiological serum by gavage daily, the sham group getting 0.25 ml of olive oil, and the HEPM 250, 500, and 500 per se group taking HEPM by gavage daily. PCOS was induced with estradiol valerate (EV), which was administered through a subcutaneous injection at 2 mg/kg volume using 0.25 ml of olive oil. After experiments, all animals were subjected to anesthesia, and serums were extracted for biochemical and hormonal evaluation. Results: EV showed marked increases in serum levels of testosterone and luteinizing hormone when compared with the control group. Significantly, the EV group decreased 17-β estradiol, progesterone, and follicle-stimulating hormone. There was a significant alteration in hormonal levels across the treatment groups. The serum malondialdehyde levels and total oxidant status were elevated in the EV group. In addition, the serum levels of total antioxidant capacity, glutathione, and glutathione peroxidase were significantly lower in the EV group than in control rats. In the treatment groups, HEPM significantly reverses the oxidant/antioxidant balance and ameliorates the adverse effect of PCOS on oxidative stress. Conclusion: The study findings indicated that the HEPM effectively safeguarded ovarian tissue from developing PCOS in the presence of EV.https://journals.lww.com/10.4103/wjtcm.wjtcm_65_24estradiol valeratephoenix dactyliferapolycystic ovary syndromerat |
| spellingShingle | Ghofran Hadi Mashkour Sangar Naser Mirazi Nasim Hayati Roodbari Abdolkarim Hossieni Nutritional Value of Palm Meristem from Phoenix dactylifera L. and Its Effect on Polycystic Ovary Syndrome in Female Rats Induced with Estradiol Valerate World Journal of Traditional Chinese Medicine estradiol valerate phoenix dactylifera polycystic ovary syndrome rat |
| title | Nutritional Value of Palm Meristem from Phoenix dactylifera L. and Its Effect on Polycystic Ovary Syndrome in Female Rats Induced with Estradiol Valerate |
| title_full | Nutritional Value of Palm Meristem from Phoenix dactylifera L. and Its Effect on Polycystic Ovary Syndrome in Female Rats Induced with Estradiol Valerate |
| title_fullStr | Nutritional Value of Palm Meristem from Phoenix dactylifera L. and Its Effect on Polycystic Ovary Syndrome in Female Rats Induced with Estradiol Valerate |
| title_full_unstemmed | Nutritional Value of Palm Meristem from Phoenix dactylifera L. and Its Effect on Polycystic Ovary Syndrome in Female Rats Induced with Estradiol Valerate |
| title_short | Nutritional Value of Palm Meristem from Phoenix dactylifera L. and Its Effect on Polycystic Ovary Syndrome in Female Rats Induced with Estradiol Valerate |
| title_sort | nutritional value of palm meristem from phoenix dactylifera l and its effect on polycystic ovary syndrome in female rats induced with estradiol valerate |
| topic | estradiol valerate phoenix dactylifera polycystic ovary syndrome rat |
| url | https://journals.lww.com/10.4103/wjtcm.wjtcm_65_24 |
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