Prognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis-associated encephalopathy
ObjectivesSepsis-associated encephalopathy (SAE) has a high incidence and mortality, especially for elderly patients and patients who are positive for pathogenic microbial infection, this study explored the prognostic factors influencing the prognosis of elderly patients with pathogenic microorganis...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1509726/full |
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| author | Xiaopeng Shi Lijun Xu Lijuan Jing Zehua Wang Lina Zhao Xiangmei Zhao |
| author_facet | Xiaopeng Shi Lijun Xu Lijuan Jing Zehua Wang Lina Zhao Xiangmei Zhao |
| author_sort | Xiaopeng Shi |
| collection | DOAJ |
| description | ObjectivesSepsis-associated encephalopathy (SAE) has a high incidence and mortality, especially for elderly patients and patients who are positive for pathogenic microbial infection, this study explored the prognostic factors influencing the prognosis of elderly patients with pathogenic microorganisms positive of sepsis-associated encephalopathy.MethodsPatients with SAE and pathogenic microbiology positive were included in this study from Medical Information Mart for Intensive Care IV (MIMIC IV) database. The main results of this study was analyzed the 28-day mortality rate of patients with pathogenic microorganism positive and SAE by Wilcoxon, Kaplan–Meier curve and other methods.ResultsThis study found that older patients with SAE had higher mortality at 28 and 90 days compared with non-older patients with SAE. Klebsiella pneumoniae and Pseudomonas aeruginosa infection, the level of APTT and lactate and SAPS III score were independent risk factors for 28-day mortality in elderly patients with SAE, among them, Klebsiella pneumoniae and Pseudomonas aeruginosa infection had the best sensitivity (0.893; 0.931) in assessing elderly patients with pathogenic microorganisms positive and SAE; the SAPS III score had the highest AUC (0.681) value and specificity (0.761) in assessing elderly patients with pathogenic microorganisms positive and SAE.ConclusionThe older patients with SAE had a poor prognosis, the elder patients with pathogenic microorganisms positive and SAE with high levels of APTT and lactate and SAPS III score and Klebsiella pneumoniae and Pseudomonas aeruginosa infection should be closely monitored and treated aggressively. |
| format | Article |
| id | doaj-art-40e4c5eadc5746a6b77296c2928b8e76 |
| institution | DOAJ |
| issn | 1664-302X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-40e4c5eadc5746a6b77296c2928b8e762025-08-20T02:56:03ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-12-011510.3389/fmicb.2024.15097261509726Prognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis-associated encephalopathyXiaopeng Shi0Lijun Xu1Lijuan Jing2Zehua Wang3Lina Zhao4Xiangmei Zhao5Department of Emergency, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, ChinaDepartment of Emergency, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, ChinaDepartment of Emergency, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, ChinaDepartment of Emergency, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, ChinaDepartment of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Emergency, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, ChinaObjectivesSepsis-associated encephalopathy (SAE) has a high incidence and mortality, especially for elderly patients and patients who are positive for pathogenic microbial infection, this study explored the prognostic factors influencing the prognosis of elderly patients with pathogenic microorganisms positive of sepsis-associated encephalopathy.MethodsPatients with SAE and pathogenic microbiology positive were included in this study from Medical Information Mart for Intensive Care IV (MIMIC IV) database. The main results of this study was analyzed the 28-day mortality rate of patients with pathogenic microorganism positive and SAE by Wilcoxon, Kaplan–Meier curve and other methods.ResultsThis study found that older patients with SAE had higher mortality at 28 and 90 days compared with non-older patients with SAE. Klebsiella pneumoniae and Pseudomonas aeruginosa infection, the level of APTT and lactate and SAPS III score were independent risk factors for 28-day mortality in elderly patients with SAE, among them, Klebsiella pneumoniae and Pseudomonas aeruginosa infection had the best sensitivity (0.893; 0.931) in assessing elderly patients with pathogenic microorganisms positive and SAE; the SAPS III score had the highest AUC (0.681) value and specificity (0.761) in assessing elderly patients with pathogenic microorganisms positive and SAE.ConclusionThe older patients with SAE had a poor prognosis, the elder patients with pathogenic microorganisms positive and SAE with high levels of APTT and lactate and SAPS III score and Klebsiella pneumoniae and Pseudomonas aeruginosa infection should be closely monitored and treated aggressively.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1509726/fullsepsissepsis-associated encephalopathyprognosisSAPS IIIpathogenic microorganisms |
| spellingShingle | Xiaopeng Shi Lijun Xu Lijuan Jing Zehua Wang Lina Zhao Xiangmei Zhao Prognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis-associated encephalopathy Frontiers in Microbiology sepsis sepsis-associated encephalopathy prognosis SAPS III pathogenic microorganisms |
| title | Prognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis-associated encephalopathy |
| title_full | Prognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis-associated encephalopathy |
| title_fullStr | Prognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis-associated encephalopathy |
| title_full_unstemmed | Prognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis-associated encephalopathy |
| title_short | Prognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis-associated encephalopathy |
| title_sort | prognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis associated encephalopathy |
| topic | sepsis sepsis-associated encephalopathy prognosis SAPS III pathogenic microorganisms |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1509726/full |
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