The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series
Background. Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na+, K+-ATPase causing lysis of highly malignant cancer cells. Hypothesis/Objectives. TOL offers an option for treating ad...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Veterinary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/2747108 |
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| author | Harry J. Gould Samantha Edenfield Paige R. Miller Kelly Jean Sherman Brian Melius Alissa Whitney Robert P. Hunter Fabio Del Piero Dennis Tracey Dennis Paul |
| author_facet | Harry J. Gould Samantha Edenfield Paige R. Miller Kelly Jean Sherman Brian Melius Alissa Whitney Robert P. Hunter Fabio Del Piero Dennis Tracey Dennis Paul |
| author_sort | Harry J. Gould |
| collection | DOAJ |
| description | Background. Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na+, K+-ATPase causing lysis of highly malignant cancer cells. Hypothesis/Objectives. TOL offers an option for treating advanced carcinomas in companion animals. Animals. Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma. Methods. Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivability varied, based on the patient’s premorbid functioning and response to treatment. Results. Regardless of cancer type, TOL consistently increased survival beyond expected, often improving, but without compromising of quality of life. Conclusions and Clinical Importance. TOL warrants consideration as an option for managing advanced carcinomas. |
| format | Article |
| id | doaj-art-40e47e30c88e4c4abff320e6a3008993 |
| institution | OA Journals |
| issn | 2090-701X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Veterinary Medicine |
| spelling | doaj-art-40e47e30c88e4c4abff320e6a30089932025-08-20T02:07:51ZengWileyCase Reports in Veterinary Medicine2090-701X2022-01-01202210.1155/2022/2747108The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case SeriesHarry J. Gould0Samantha Edenfield1Paige R. Miller2Kelly Jean Sherman3Brian Melius4Alissa Whitney5Robert P. Hunter6Fabio Del Piero7Dennis Tracey8Dennis Paul9Department of NeurologyDepartment of Pharmacology and Experimental TherapeuticsOleander Medical TechnologiesDepartment of Pharmacology and Experimental TherapeuticsMetairie Small Animal HospitalMonroe Street Animal HospitalOne Medicine ConsultingDepartment of Pathobiological Sciences and Louisiana Animal Disease Diagnostic Laboratory (LADDL)Oleander Medical TechnologiesOleander Medical TechnologiesBackground. Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na+, K+-ATPase causing lysis of highly malignant cancer cells. Hypothesis/Objectives. TOL offers an option for treating advanced carcinomas in companion animals. Animals. Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma. Methods. Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivability varied, based on the patient’s premorbid functioning and response to treatment. Results. Regardless of cancer type, TOL consistently increased survival beyond expected, often improving, but without compromising of quality of life. Conclusions and Clinical Importance. TOL warrants consideration as an option for managing advanced carcinomas.http://dx.doi.org/10.1155/2022/2747108 |
| spellingShingle | Harry J. Gould Samantha Edenfield Paige R. Miller Kelly Jean Sherman Brian Melius Alissa Whitney Robert P. Hunter Fabio Del Piero Dennis Tracey Dennis Paul The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series Case Reports in Veterinary Medicine |
| title | The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series |
| title_full | The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series |
| title_fullStr | The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series |
| title_full_unstemmed | The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series |
| title_short | The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series |
| title_sort | role of targeted osmotic lysis in the treatment of advanced carcinoma in companion animals a case series |
| url | http://dx.doi.org/10.1155/2022/2747108 |
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