Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional study
Abstract Background It is known that the risk of ischemic heart disease increases in patients with type 2 diabetes mellitus (T2DM). For female patients, the incidence of heart disease can be even greater after menopause, accompanied by dramatic changes in sex hormones. We investigated the correlatio...
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Wiley
2024-10-01
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| Series: | Journal of Diabetes |
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| Online Access: | https://doi.org/10.1111/1753-0407.70005 |
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| author | Yahao Wang Yixuan Li Chuanfeng Liu Yangang Wang Yiming Li |
| author_facet | Yahao Wang Yixuan Li Chuanfeng Liu Yangang Wang Yiming Li |
| author_sort | Yahao Wang |
| collection | DOAJ |
| description | Abstract Background It is known that the risk of ischemic heart disease increases in patients with type 2 diabetes mellitus (T2DM). For female patients, the incidence of heart disease can be even greater after menopause, accompanied by dramatic changes in sex hormones. We investigated the correlations between sex hormones and markers of ischemic heart diseases in postmenopausal females with T2DM patients. Methods This cross‐sectional study collected data from 324 hospitalized postmenopausal females with T2DM. Multiple linear regression analyses were conducted to determine the correlations between sex hormones and cardiac markers including high‐sensitive cardiac troponin T (hs‐cTnT) and N‐terminal prohormone of brain natriuretic peptide (NT‐proBNP) levels. Results Multiple linear regression analyses revealed that luteinizing hormone (LH) was positively and independently associated with hs‐cTnT concentrations in postmenopausal females with T2DM (β = 0.189, p = 0.002). Postmenopausal females with T2DM and subclinical myocardial injury had higher LH levels than those without subclinical myocardial injury (29.67 vs. 25.08 mIU/mL, p < 0.001). A multivariate logistic regression analysis confirmed an independent and significant association between elevated LH and subclinical myocardial injury in postmenopausal females with T2DM (adjusted odds ratio [OR] = 1.077, 95% confidence interval [CI], 1.033–1.124; p < 0.001). As another gonadotropin, the follicle‐stimulating hormone did not show independent correlations with hs‐cTnT or NT‐proBNP (p > 0.05). Neither estrogen nor testosterone was correlated with cardiac markers. Conclusions Elevated LH levels were positively and independently associated with increased hs‐cTnT levels in postmenopausal women with T2DM. Our findings suggest that LH could serve as a potential marker for assessing the risk of subclinical myocardial injury in postmenopausal females with T2DM. |
| format | Article |
| id | doaj-art-40e2d1c396414f4f87949b554e08329b |
| institution | DOAJ |
| issn | 1753-0393 1753-0407 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
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| series | Journal of Diabetes |
| spelling | doaj-art-40e2d1c396414f4f87949b554e08329b2025-08-20T02:50:48ZengWileyJournal of Diabetes1753-03931753-04072024-10-011610n/an/a10.1111/1753-0407.70005Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional studyYahao Wang0Yixuan Li1Chuanfeng Liu2Yangang Wang3Yiming Li4Department of Endocrinology, Huashan Hospital Fudan University Shanghai ChinaDepartment of Endocrinology The Affiliated Hospital of Qingdao University Qingdao ChinaDepartment of Endocrinology The Affiliated Hospital of Qingdao University Qingdao ChinaDepartment of Endocrinology The Affiliated Hospital of Qingdao University Qingdao ChinaDepartment of Endocrinology, Huashan Hospital Fudan University Shanghai ChinaAbstract Background It is known that the risk of ischemic heart disease increases in patients with type 2 diabetes mellitus (T2DM). For female patients, the incidence of heart disease can be even greater after menopause, accompanied by dramatic changes in sex hormones. We investigated the correlations between sex hormones and markers of ischemic heart diseases in postmenopausal females with T2DM patients. Methods This cross‐sectional study collected data from 324 hospitalized postmenopausal females with T2DM. Multiple linear regression analyses were conducted to determine the correlations between sex hormones and cardiac markers including high‐sensitive cardiac troponin T (hs‐cTnT) and N‐terminal prohormone of brain natriuretic peptide (NT‐proBNP) levels. Results Multiple linear regression analyses revealed that luteinizing hormone (LH) was positively and independently associated with hs‐cTnT concentrations in postmenopausal females with T2DM (β = 0.189, p = 0.002). Postmenopausal females with T2DM and subclinical myocardial injury had higher LH levels than those without subclinical myocardial injury (29.67 vs. 25.08 mIU/mL, p < 0.001). A multivariate logistic regression analysis confirmed an independent and significant association between elevated LH and subclinical myocardial injury in postmenopausal females with T2DM (adjusted odds ratio [OR] = 1.077, 95% confidence interval [CI], 1.033–1.124; p < 0.001). As another gonadotropin, the follicle‐stimulating hormone did not show independent correlations with hs‐cTnT or NT‐proBNP (p > 0.05). Neither estrogen nor testosterone was correlated with cardiac markers. Conclusions Elevated LH levels were positively and independently associated with increased hs‐cTnT levels in postmenopausal women with T2DM. Our findings suggest that LH could serve as a potential marker for assessing the risk of subclinical myocardial injury in postmenopausal females with T2DM.https://doi.org/10.1111/1753-0407.70005hs‐cTnTluteinizing hormonepostmenopausesubclinical myocardial necrosistype 2 diabetes mellitus |
| spellingShingle | Yahao Wang Yixuan Li Chuanfeng Liu Yangang Wang Yiming Li Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional study Journal of Diabetes hs‐cTnT luteinizing hormone postmenopause subclinical myocardial necrosis type 2 diabetes mellitus |
| title | Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional study |
| title_full | Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional study |
| title_fullStr | Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional study |
| title_full_unstemmed | Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional study |
| title_short | Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional study |
| title_sort | luteinizing hormone is independently associated with high sensitive cardiac troponin t elevation in postmenopausal t2dm patients a cross sectional study |
| topic | hs‐cTnT luteinizing hormone postmenopause subclinical myocardial necrosis type 2 diabetes mellitus |
| url | https://doi.org/10.1111/1753-0407.70005 |
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