An Overview of Hormone-Sensitive Lipase (HSL)
Hormone-sensitive lipase (HSL) is a pivotal enzyme that mediates triglyceride hydrolysis to provide free fatty acids and glycerol in adipocytes in a hormonally controlled lipolysis process. Elevated plasma-free fatty acids were accompanied by insulin resistance, type-2 diabetes, and obesity. Inhibit...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2022/1964684 |
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| _version_ | 1850218166198730752 |
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| author | Arwa R. Althaher |
| author_facet | Arwa R. Althaher |
| author_sort | Arwa R. Althaher |
| collection | DOAJ |
| description | Hormone-sensitive lipase (HSL) is a pivotal enzyme that mediates triglyceride hydrolysis to provide free fatty acids and glycerol in adipocytes in a hormonally controlled lipolysis process. Elevated plasma-free fatty acids were accompanied by insulin resistance, type-2 diabetes, and obesity. Inhibition of lipolysis through HSL inhibition may provide a mechanism to prevent the accumulation of free fatty acids and to improve the affectability of insulin and blood glucose handling in type II diabetes. The published studies that examine the structure, regulation, and function of HSL and major inhibitors were reviewed in this paper. |
| format | Article |
| id | doaj-art-40e2a119525f49dd8039f5e4df343476 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-40e2a119525f49dd8039f5e4df3434762025-08-20T02:07:51ZengWileyThe Scientific World Journal1537-744X2022-01-01202210.1155/2022/1964684An Overview of Hormone-Sensitive Lipase (HSL)Arwa R. Althaher0Department of PharmacyHormone-sensitive lipase (HSL) is a pivotal enzyme that mediates triglyceride hydrolysis to provide free fatty acids and glycerol in adipocytes in a hormonally controlled lipolysis process. Elevated plasma-free fatty acids were accompanied by insulin resistance, type-2 diabetes, and obesity. Inhibition of lipolysis through HSL inhibition may provide a mechanism to prevent the accumulation of free fatty acids and to improve the affectability of insulin and blood glucose handling in type II diabetes. The published studies that examine the structure, regulation, and function of HSL and major inhibitors were reviewed in this paper.http://dx.doi.org/10.1155/2022/1964684 |
| spellingShingle | Arwa R. Althaher An Overview of Hormone-Sensitive Lipase (HSL) The Scientific World Journal |
| title | An Overview of Hormone-Sensitive Lipase (HSL) |
| title_full | An Overview of Hormone-Sensitive Lipase (HSL) |
| title_fullStr | An Overview of Hormone-Sensitive Lipase (HSL) |
| title_full_unstemmed | An Overview of Hormone-Sensitive Lipase (HSL) |
| title_short | An Overview of Hormone-Sensitive Lipase (HSL) |
| title_sort | overview of hormone sensitive lipase hsl |
| url | http://dx.doi.org/10.1155/2022/1964684 |
| work_keys_str_mv | AT arwaralthaher anoverviewofhormonesensitivelipasehsl AT arwaralthaher overviewofhormonesensitivelipasehsl |